Hypoglycemia and risk of death in critically ill patients

Simon R Finfer, Bette Liu, Dean R Chittock, Robyn Norton, John A Myburgh, Colin McArthur, Imogen Mitchell, Denise Foster, Vinay Dhingra, William R Henderson, Juan J Ronco, Rinaldo Bellomo, Deborah J Cook, Ellen McDonald, Peter Dodek, Paul Hebert, Daren K Heyland, Bruce Robinson

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Abstract

Whether hypoglycemia leads to death in critically ill patients is unclear. METHODS: We examined the associations between moderate and severe hypoglycemia (blood glucose, 41 to 70 mg per deciliter [2.3 to 3.9 mmol per liter] and =40 mg per deciliter [2.2 mmol per liter], respectively) and death among 6026 critically ill patients in intensive care units (ICUs). Patients were randomly assigned to intensive or conventional glucose control. We used Cox regression analysis with adjustment for treatment assignment and for baseline and postrandomization covariates.
Original languageEnglish
Pages (from-to)1108 - 1118
Number of pages11
JournalThe New England Journal of Medicine
Volume367
Issue number12
DOIs
Publication statusPublished - 2012
Externally publishedYes

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