Hypoglycaemic activity of an analogue of human growth hormone [6-13] incorporating a d-ala-pro dipeptide unit

Philip E. Thompson, Noel Lim, Effendi Wijaya, Frank M. Ng, Milton T.W. Hearn

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9 Citations (Scopus)

Abstract

An analogue of human Growth Hormone [6-13] has been prepared incorporating a d-Ala11-Pro12 dipeptide unit to induce a type II′ β-turn conformation. Similar hypoglycaemic activity has been observed to that of the aspartimide-containing analogue Asu11-hGH[6-13], indicating conservation of bioactive conformation properties.

Original languageEnglish
Pages (from-to)1625-1628
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume3
Issue number8
DOIs
Publication statusPublished - 1 Jan 1993

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