Abstract
An analogue of human Growth Hormone [6-13] has been prepared incorporating a d-Ala11-Pro12 dipeptide unit to induce a type II′ β-turn conformation. Similar hypoglycaemic activity has been observed to that of the aspartimide-containing analogue Asu11-hGH[6-13], indicating conservation of bioactive conformation properties.
Original language | English |
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Pages (from-to) | 1625-1628 |
Number of pages | 4 |
Journal | Bioorganic and Medicinal Chemistry Letters |
Volume | 3 |
Issue number | 8 |
DOIs | |
Publication status | Published - 1 Jan 1993 |