Hyperpolarised gas filling station for medical imaging using polarised 129Xe and 3He

Wai Tung Lee, Gang Zheng, Cavin L. Talbot, Xin Tong, Tim D'Adam, Steven R. Parnell, Michael De Veer, Graham Jenkin, Graeme R. Polglase, Stuart B Hooper, Bruce R. Thompson, Francis Thien, Gary F. Egan

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We report the design, construction, and initial tests of a hyperpolariser to produce polarised 129Xe and 3He gas for medical imaging of the lung. The hyperpolariser uses the Spin-Exchange Optical Pumping method to polarise the nuclear spins of the isotopic gas. Batch mode operation was chosen for the design to produce polarised 129Xe and polarised 3He. Two-side pumping, electrical heating and a piston to transfer the polarised gas were some of the implemented techniques that are not commonly used in hyperpolariser designs. We have carried out magnetic resonance imaging experiments demonstrating that the 3He and 129Xe polarisation reached were sufficient for imaging, in particular for in vivo lung imaging using 129Xe. Further improvements to the hyperpolariser have also been discussed.

Original languageEnglish
Pages (from-to)112-120
Number of pages9
JournalMagnetic Resonance Imaging
Publication statusPublished - Jun 2021


  • Hyperpolariser
  • Hyperpolarised Xenon-129
  • Hyperpolarised Helium-3
  • MRI lung imaging: Spin-exchange optical pumping

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