Hyperoxia in the intensive care unit and outcome after out-of-hospital ventricular fibrillation cardiac arrest

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Abstract

Laboratory and clinical studies have suggested that hyperoxia early after resuscitation from cardiac arrest may increase neurological injury and worsen outcome. Previous clinical studies have been small or have not included relevant prehospital data. We aimed to determine in a larger cohort of patients whether hyperoxia in the intensive care unit in patients admitted after out-ofhospital cardiac arrest (OHCA) was associated with increased mortality rate after correction for prehospital variables. METHODS: Data from the Victorian Ambulance Cardiac Arrest Registry (VACAR) of patients transported to hospital after resuscitation from OHCA and an initial cardiac rhythm of ventricular fibrillation between January 2007 and December 2011 were linked to the Australian and New Zealand Intensive Care Society Adult Patient Database (ANZICS-APD). Patients were allocated into three groups (hypoxia [PaO2
Original languageEnglish
Pages (from-to)186 - 190
Number of pages5
JournalCritical Care and Resuscitation
Volume15
Issue number3
Publication statusPublished - 2013

Cite this

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title = "Hyperoxia in the intensive care unit and outcome after out-of-hospital ventricular fibrillation cardiac arrest",
abstract = "Laboratory and clinical studies have suggested that hyperoxia early after resuscitation from cardiac arrest may increase neurological injury and worsen outcome. Previous clinical studies have been small or have not included relevant prehospital data. We aimed to determine in a larger cohort of patients whether hyperoxia in the intensive care unit in patients admitted after out-ofhospital cardiac arrest (OHCA) was associated with increased mortality rate after correction for prehospital variables. METHODS: Data from the Victorian Ambulance Cardiac Arrest Registry (VACAR) of patients transported to hospital after resuscitation from OHCA and an initial cardiac rhythm of ventricular fibrillation between January 2007 and December 2011 were linked to the Australian and New Zealand Intensive Care Society Adult Patient Database (ANZICS-APD). Patients were allocated into three groups (hypoxia [PaO2",
author = "Ihle, {Joshua F} and Bernard, {Stephen Anthony} and Bailey, {Michael John} and Pilcher, {David V} and Smith, {Karen Louise} and Scheinkestel, {Carlos D}",
year = "2013",
language = "English",
volume = "15",
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journal = "Critical Care and Resuscitation",
issn = "1441-2772",
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number = "3",

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TY - JOUR

T1 - Hyperoxia in the intensive care unit and outcome after out-of-hospital ventricular fibrillation cardiac arrest

AU - Ihle, Joshua F

AU - Bernard, Stephen Anthony

AU - Bailey, Michael John

AU - Pilcher, David V

AU - Smith, Karen Louise

AU - Scheinkestel, Carlos D

PY - 2013

Y1 - 2013

N2 - Laboratory and clinical studies have suggested that hyperoxia early after resuscitation from cardiac arrest may increase neurological injury and worsen outcome. Previous clinical studies have been small or have not included relevant prehospital data. We aimed to determine in a larger cohort of patients whether hyperoxia in the intensive care unit in patients admitted after out-ofhospital cardiac arrest (OHCA) was associated with increased mortality rate after correction for prehospital variables. METHODS: Data from the Victorian Ambulance Cardiac Arrest Registry (VACAR) of patients transported to hospital after resuscitation from OHCA and an initial cardiac rhythm of ventricular fibrillation between January 2007 and December 2011 were linked to the Australian and New Zealand Intensive Care Society Adult Patient Database (ANZICS-APD). Patients were allocated into three groups (hypoxia [PaO2

AB - Laboratory and clinical studies have suggested that hyperoxia early after resuscitation from cardiac arrest may increase neurological injury and worsen outcome. Previous clinical studies have been small or have not included relevant prehospital data. We aimed to determine in a larger cohort of patients whether hyperoxia in the intensive care unit in patients admitted after out-ofhospital cardiac arrest (OHCA) was associated with increased mortality rate after correction for prehospital variables. METHODS: Data from the Victorian Ambulance Cardiac Arrest Registry (VACAR) of patients transported to hospital after resuscitation from OHCA and an initial cardiac rhythm of ventricular fibrillation between January 2007 and December 2011 were linked to the Australian and New Zealand Intensive Care Society Adult Patient Database (ANZICS-APD). Patients were allocated into three groups (hypoxia [PaO2

UR - http://www.ncbi.nlm.nih.gov/pubmed/23944204

M3 - Article

VL - 15

SP - 186

EP - 190

JO - Critical Care and Resuscitation

JF - Critical Care and Resuscitation

SN - 1441-2772

IS - 3

ER -