Hyperoxia in the intensive care unit and outcome after out-of-hospital ventricular fibrillation cardiac arrest

Joshua F Ihle, Stephen Anthony Bernard, Michael John Bailey, David V Pilcher, Karen Louise Smith, Carlos D Scheinkestel

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Laboratory and clinical studies have suggested that hyperoxia early after resuscitation from cardiac arrest may increase neurological injury and worsen outcome. Previous clinical studies have been small or have not included relevant prehospital data. We aimed to determine in a larger cohort of patients whether hyperoxia in the intensive care unit in patients admitted after out-ofhospital cardiac arrest (OHCA) was associated with increased mortality rate after correction for prehospital variables. METHODS: Data from the Victorian Ambulance Cardiac Arrest Registry (VACAR) of patients transported to hospital after resuscitation from OHCA and an initial cardiac rhythm of ventricular fibrillation between January 2007 and December 2011 were linked to the Australian and New Zealand Intensive Care Society Adult Patient Database (ANZICS-APD). Patients were allocated into three groups (hypoxia [PaO2
Original languageEnglish
Pages (from-to)186 - 190
Number of pages5
JournalCritical Care and Resuscitation
Issue number3
Publication statusPublished - 2013

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