HYPERLIPIDAEMIA INCREASES ALBUMINURIA IN HYPERTENSIVE AND NORMOTENSIVE RATS

M. E. Cooper; D. A. Vranes; S. Panagiotopoulos; T. J. Allen; I. Goodall; G. Jerums

doi:10.1111/j.1440-1681.1990.tb01311.x

HYPERLIPIDAEMIA INCREASES ALBUMINURIA IN HYPERTENSIVE AND NORMOTENSIVE RATS

M. E. Cooper
, D. A. Vranes
, S. Panagiotopoulos
, T. J. Allen
, I. Goodall
, G. Jerums

Research output: Contribution to journal › Article › Research › peer-review

3 Citations (Scopus)

Abstract

1. The effects of a high cholesterol diet on urinary albumin excretion were examined in spontaneously hypertensive (SHR) and Wistar‐Kyoto (WKY) rats over 36 weeks. 2. Cholesterol feeding resulted in an increase in total‐cholesterol and a decrease in HDL‐cholesterol without influencing triglyceride levels in both strains. 3. Urinary albumin excretion was significantly elevated in cholesterol‐fed SHR and WKY rats. 4. These results suggest that hyperlipidaemia may be important in acceleration of experimental nephropathy.

Original language	English
Pages (from-to)	225-228
Number of pages	4
Journal	Clinical and Experimental Pharmacology and Physiology
Volume	17
Issue number	3
DOIs	https://doi.org/10.1111/j.1440-1681.1990.tb01311.x
Publication status	Published - Mar 1990
Externally published	Yes

Keywords

albuminuria
hyperlipidaemia
hypertension
kidney
spontaneously hypertensive rat

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10.1111/j.1440-1681.1990.tb01311.x

Cite this

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title = "HYPERLIPIDAEMIA INCREASES ALBUMINURIA IN HYPERTENSIVE AND NORMOTENSIVE RATS",

abstract = "1. The effects of a high cholesterol diet on urinary albumin excretion were examined in spontaneously hypertensive (SHR) and Wistar‐Kyoto (WKY) rats over 36 weeks. 2. Cholesterol feeding resulted in an increase in total‐cholesterol and a decrease in HDL‐cholesterol without influencing triglyceride levels in both strains. 3. Urinary albumin excretion was significantly elevated in cholesterol‐fed SHR and WKY rats. 4. These results suggest that hyperlipidaemia may be important in acceleration of experimental nephropathy.",

keywords = "albuminuria, hyperlipidaemia, hypertension, kidney, spontaneously hypertensive rat",

author = "Cooper, \{M. E.\} and Vranes, \{D. A.\} and S. Panagiotopoulos and Allen, \{T. J.\} and I. Goodall and G. Jerums",

year = "1990",

month = mar,

doi = "10.1111/j.1440-1681.1990.tb01311.x",

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AU - Cooper, M. E.

AU - Vranes, D. A.

AU - Panagiotopoulos, S.

AU - Allen, T. J.

AU - Goodall, I.

AU - Jerums, G.

PY - 1990/3

Y1 - 1990/3

N2 - 1. The effects of a high cholesterol diet on urinary albumin excretion were examined in spontaneously hypertensive (SHR) and Wistar‐Kyoto (WKY) rats over 36 weeks. 2. Cholesterol feeding resulted in an increase in total‐cholesterol and a decrease in HDL‐cholesterol without influencing triglyceride levels in both strains. 3. Urinary albumin excretion was significantly elevated in cholesterol‐fed SHR and WKY rats. 4. These results suggest that hyperlipidaemia may be important in acceleration of experimental nephropathy.

AB - 1. The effects of a high cholesterol diet on urinary albumin excretion were examined in spontaneously hypertensive (SHR) and Wistar‐Kyoto (WKY) rats over 36 weeks. 2. Cholesterol feeding resulted in an increase in total‐cholesterol and a decrease in HDL‐cholesterol without influencing triglyceride levels in both strains. 3. Urinary albumin excretion was significantly elevated in cholesterol‐fed SHR and WKY rats. 4. These results suggest that hyperlipidaemia may be important in acceleration of experimental nephropathy.

KW - albuminuria

KW - hyperlipidaemia

KW - hypertension

KW - kidney

KW - spontaneously hypertensive rat

UR - https://www.scopus.com/pages/publications/0025305539

U2 - 10.1111/j.1440-1681.1990.tb01311.x

DO - 10.1111/j.1440-1681.1990.tb01311.x

M3 - Article

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AN - SCOPUS:0025305539

SN - 0305-1870

VL - 17

SP - 225

EP - 228

JO - Clinical and Experimental Pharmacology and Physiology

JF - Clinical and Experimental Pharmacology and Physiology

IS - 3

ER -

HYPERLIPIDAEMIA INCREASES ALBUMINURIA IN HYPERTENSIVE AND NORMOTENSIVE RATS

Abstract

Keywords

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