Hyperglycemia and the outcome of pediatric cardiac surgery patients requiring peritoneal dialysis

Moritoki Egi, H. Morimatsu, Y. Toda, T. Matsusaki, S. Suzuki, K. Shimizu, T. Iwasaki, M. Takeuchi, Rinaldo Bellomo, K. Morita

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Abstract

Objective: To study the nature of the association between glycemia and ICU mortality in pediatric cardiac surgery patients treated with peritoneal dialysis (PD). Materials and methods: Retrospective observational study in the ICU of a tertiary hospital involving forty pediatric cardiac surgery patients treated with PD. We selected patients requiring PD, extracted glucose measurements and nutritional intake data during ICU stay and calculated mean and maximum blood glucose values i) during ICU stay; ii) during dependence on PD, and iii) during independence from PD. We statistically assessed the relationship between glycemia-related variables and ICU mortality. Measurements and Results: Twenty-two patients treated with PD died (mortality 55%). In the PD cohort, 9725 blood glucose measurements were performed (every 3.3 hours on average). The mean glycemia during dependence on PD was significantly higher in non-survivors than survivors (p<0.0001), but not during independence from PD (p=0.49). The area under the receiver operator characteristic curve for the mean glycemia during dependence on PD was significantly greater than that obtained during independence from PD. Even after adjustment for severity of illness using multivariate logistic analysis, the mean glycemia and calorie intake during PD were significant and independent predictors: of ICU mortality. Conclusions: A higher mean blood glucose concentration during PD, but not during PD-free periods was associated with greater ICU mortality. Mean glycemia and calorie intake during PD were significant and independent predictors of ICU mortality.

Original languageEnglish
Pages (from-to)309-316
Number of pages8
JournalInternational Journal of Artificial Organs
Volume31
Issue number4
DOIs
Publication statusPublished - 1 Jan 2008
Externally publishedYes

Keywords

  • Cardiac surgery
  • Glucose
  • Insulin
  • Intensive care
  • Nutrition
  • Peritoneal dialysis

Cite this

Egi, Moritoki ; Morimatsu, H. ; Toda, Y. ; Matsusaki, T. ; Suzuki, S. ; Shimizu, K. ; Iwasaki, T. ; Takeuchi, M. ; Bellomo, Rinaldo ; Morita, K. / Hyperglycemia and the outcome of pediatric cardiac surgery patients requiring peritoneal dialysis. In: International Journal of Artificial Organs. 2008 ; Vol. 31, No. 4. pp. 309-316.
@article{d6a7ce1b36d04cbb9bea60049ff0a74a,
title = "Hyperglycemia and the outcome of pediatric cardiac surgery patients requiring peritoneal dialysis",
abstract = "Objective: To study the nature of the association between glycemia and ICU mortality in pediatric cardiac surgery patients treated with peritoneal dialysis (PD). Materials and methods: Retrospective observational study in the ICU of a tertiary hospital involving forty pediatric cardiac surgery patients treated with PD. We selected patients requiring PD, extracted glucose measurements and nutritional intake data during ICU stay and calculated mean and maximum blood glucose values i) during ICU stay; ii) during dependence on PD, and iii) during independence from PD. We statistically assessed the relationship between glycemia-related variables and ICU mortality. Measurements and Results: Twenty-two patients treated with PD died (mortality 55{\%}). In the PD cohort, 9725 blood glucose measurements were performed (every 3.3 hours on average). The mean glycemia during dependence on PD was significantly higher in non-survivors than survivors (p<0.0001), but not during independence from PD (p=0.49). The area under the receiver operator characteristic curve for the mean glycemia during dependence on PD was significantly greater than that obtained during independence from PD. Even after adjustment for severity of illness using multivariate logistic analysis, the mean glycemia and calorie intake during PD were significant and independent predictors: of ICU mortality. Conclusions: A higher mean blood glucose concentration during PD, but not during PD-free periods was associated with greater ICU mortality. Mean glycemia and calorie intake during PD were significant and independent predictors of ICU mortality.",
keywords = "Cardiac surgery, Glucose, Insulin, Intensive care, Nutrition, Peritoneal dialysis",
author = "Moritoki Egi and H. Morimatsu and Y. Toda and T. Matsusaki and S. Suzuki and K. Shimizu and T. Iwasaki and M. Takeuchi and Rinaldo Bellomo and K. Morita",
year = "2008",
month = "1",
day = "1",
doi = "10.1177/039139880803100406",
language = "English",
volume = "31",
pages = "309--316",
journal = "International Journal of Artificial Organs",
issn = "0391-3988",
publisher = "Wichtig",
number = "4",

}

Egi, M, Morimatsu, H, Toda, Y, Matsusaki, T, Suzuki, S, Shimizu, K, Iwasaki, T, Takeuchi, M, Bellomo, R & Morita, K 2008, 'Hyperglycemia and the outcome of pediatric cardiac surgery patients requiring peritoneal dialysis', International Journal of Artificial Organs, vol. 31, no. 4, pp. 309-316. https://doi.org/10.1177/039139880803100406

Hyperglycemia and the outcome of pediatric cardiac surgery patients requiring peritoneal dialysis. / Egi, Moritoki; Morimatsu, H.; Toda, Y.; Matsusaki, T.; Suzuki, S.; Shimizu, K.; Iwasaki, T.; Takeuchi, M.; Bellomo, Rinaldo; Morita, K.

In: International Journal of Artificial Organs, Vol. 31, No. 4, 01.01.2008, p. 309-316.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Hyperglycemia and the outcome of pediatric cardiac surgery patients requiring peritoneal dialysis

AU - Egi, Moritoki

AU - Morimatsu, H.

AU - Toda, Y.

AU - Matsusaki, T.

AU - Suzuki, S.

AU - Shimizu, K.

AU - Iwasaki, T.

AU - Takeuchi, M.

AU - Bellomo, Rinaldo

AU - Morita, K.

PY - 2008/1/1

Y1 - 2008/1/1

N2 - Objective: To study the nature of the association between glycemia and ICU mortality in pediatric cardiac surgery patients treated with peritoneal dialysis (PD). Materials and methods: Retrospective observational study in the ICU of a tertiary hospital involving forty pediatric cardiac surgery patients treated with PD. We selected patients requiring PD, extracted glucose measurements and nutritional intake data during ICU stay and calculated mean and maximum blood glucose values i) during ICU stay; ii) during dependence on PD, and iii) during independence from PD. We statistically assessed the relationship between glycemia-related variables and ICU mortality. Measurements and Results: Twenty-two patients treated with PD died (mortality 55%). In the PD cohort, 9725 blood glucose measurements were performed (every 3.3 hours on average). The mean glycemia during dependence on PD was significantly higher in non-survivors than survivors (p<0.0001), but not during independence from PD (p=0.49). The area under the receiver operator characteristic curve for the mean glycemia during dependence on PD was significantly greater than that obtained during independence from PD. Even after adjustment for severity of illness using multivariate logistic analysis, the mean glycemia and calorie intake during PD were significant and independent predictors: of ICU mortality. Conclusions: A higher mean blood glucose concentration during PD, but not during PD-free periods was associated with greater ICU mortality. Mean glycemia and calorie intake during PD were significant and independent predictors of ICU mortality.

AB - Objective: To study the nature of the association between glycemia and ICU mortality in pediatric cardiac surgery patients treated with peritoneal dialysis (PD). Materials and methods: Retrospective observational study in the ICU of a tertiary hospital involving forty pediatric cardiac surgery patients treated with PD. We selected patients requiring PD, extracted glucose measurements and nutritional intake data during ICU stay and calculated mean and maximum blood glucose values i) during ICU stay; ii) during dependence on PD, and iii) during independence from PD. We statistically assessed the relationship between glycemia-related variables and ICU mortality. Measurements and Results: Twenty-two patients treated with PD died (mortality 55%). In the PD cohort, 9725 blood glucose measurements were performed (every 3.3 hours on average). The mean glycemia during dependence on PD was significantly higher in non-survivors than survivors (p<0.0001), but not during independence from PD (p=0.49). The area under the receiver operator characteristic curve for the mean glycemia during dependence on PD was significantly greater than that obtained during independence from PD. Even after adjustment for severity of illness using multivariate logistic analysis, the mean glycemia and calorie intake during PD were significant and independent predictors: of ICU mortality. Conclusions: A higher mean blood glucose concentration during PD, but not during PD-free periods was associated with greater ICU mortality. Mean glycemia and calorie intake during PD were significant and independent predictors of ICU mortality.

KW - Cardiac surgery

KW - Glucose

KW - Insulin

KW - Intensive care

KW - Nutrition

KW - Peritoneal dialysis

UR - http://www.scopus.com/inward/record.url?scp=45949098695&partnerID=8YFLogxK

U2 - 10.1177/039139880803100406

DO - 10.1177/039139880803100406

M3 - Article

C2 - 18432586

AN - SCOPUS:45949098695

VL - 31

SP - 309

EP - 316

JO - International Journal of Artificial Organs

JF - International Journal of Artificial Organs

SN - 0391-3988

IS - 4

ER -