TY - JOUR
T1 - Hyperemesis gravidarum severity, enteral tube feeding and cardiometabolic markers in offspring cord blood
AU - Nijsten, Kelly
AU - Koot, Marjette H.
AU - Bais, Joke M.J.
AU - Ris-Stalpers, Carrie
AU - Van Eekelen, Rik
AU - Bremer, Henk A.
AU - Van Der Ham, David P.
AU - Heidema, Wieteke M.
AU - Huisjes, Anjoke
AU - Kleiverda, Gunilla
AU - Kruizenga, Hinke
AU - Kuppens, Simone M.
AU - Van Laar, Judith O.E.H.
AU - Langenveld, Josje
AU - Van Der Made, Flip
AU - Papatsonis, Dimitri
AU - Pelinck, Marie José
AU - Pernet, Paula J.
AU - Van Rheenen-Flach, Leonie
AU - Rijnders, Robbert J.
AU - Scheepers, Hubertina C.J.
AU - Vogelvang, Tatjana
AU - Mol, Ben W.
AU - Grooten, Iris J.
AU - Roseboom, Tessa J.
AU - Painter, Rebecca C.
N1 - Publisher Copyright:
© The Authors 2022.
PY - 2022/12/28
Y1 - 2022/12/28
N2 - The present study aimed to investigate the association between hyperemesis gravidarum (HG) severity and the effect of early enteral tube feeding on cardiometabolic markers in offspring cord blood. We included women admitted for HG, who participated in the MOTHER randomized controlled trial (RCT) and observational cohort. The MOTHER RCT showed that early enteral tube feeding in addition to standard care did not affect symptoms or birth outcomes. Among RCT and cohort participants, we assessed how HG severity affected lipid, c-peptide, glucose and free thyroxine cord blood levels. HG severity measures were: severity of vomiting at inclusion and three weeks after inclusion, pregnancy weight gain and 24-hour energy intake at inclusion, readmissions and duration of hospital admissions. Cord blood measures were also compared between RCT participants allocated to enteral tube feeding and those receiving standard care. Between 2013-2016, 215 women were included: 115 RCT and 100 cohort participants. Eighty-one cord blood samples were available. Univariable, not multivariable regression analysis showed that lower maternal weight gain was associated with higher cord blood glucose levels (β:-0.08, 95% CI:-0.16;-0.00). Lower maternal weight gain was associated with higher apolipoprotein-B cord blood levels in multivariable regression analysis (β:-0.01, 95% CI:-0.02;-0.01). No associations were found between other HG severity measures or allocation to enteral tube feeding and cord blood cardiometabolic markers. In conclusion, while lower maternal weight gain was associated with higher apolipoprotein-B cord blood levels, no other HG severity measures were linked with cord blood cardiometabolic markers, nor were these markers affected by enteral tube feeding.
AB - The present study aimed to investigate the association between hyperemesis gravidarum (HG) severity and the effect of early enteral tube feeding on cardiometabolic markers in offspring cord blood. We included women admitted for HG, who participated in the MOTHER randomized controlled trial (RCT) and observational cohort. The MOTHER RCT showed that early enteral tube feeding in addition to standard care did not affect symptoms or birth outcomes. Among RCT and cohort participants, we assessed how HG severity affected lipid, c-peptide, glucose and free thyroxine cord blood levels. HG severity measures were: severity of vomiting at inclusion and three weeks after inclusion, pregnancy weight gain and 24-hour energy intake at inclusion, readmissions and duration of hospital admissions. Cord blood measures were also compared between RCT participants allocated to enteral tube feeding and those receiving standard care. Between 2013-2016, 215 women were included: 115 RCT and 100 cohort participants. Eighty-one cord blood samples were available. Univariable, not multivariable regression analysis showed that lower maternal weight gain was associated with higher cord blood glucose levels (β:-0.08, 95% CI:-0.16;-0.00). Lower maternal weight gain was associated with higher apolipoprotein-B cord blood levels in multivariable regression analysis (β:-0.01, 95% CI:-0.02;-0.01). No associations were found between other HG severity measures or allocation to enteral tube feeding and cord blood cardiometabolic markers. In conclusion, while lower maternal weight gain was associated with higher apolipoprotein-B cord blood levels, no other HG severity measures were linked with cord blood cardiometabolic markers, nor were these markers affected by enteral tube feeding.
KW - Cardiometabolic risk factors
KW - cardiovascular diseases
KW - fetal blood
KW - fetal nutrition disorders
KW - hyperemesis gravidarum
KW - nutrition
UR - https://www.scopus.com/pages/publications/85125583990
U2 - 10.1017/S0007114522000587
DO - 10.1017/S0007114522000587
M3 - Article
C2 - 35197140
AN - SCOPUS:85125583990
SN - 0007-1145
VL - 128
SP - 2421
EP - 2431
JO - British Journal of Nutrition
JF - British Journal of Nutrition
IS - 12
ER -
SDG 3 Good Health and Well-being