TY - JOUR
T1 - Hydrogen peroxide as an immunological transmitter regulating autoreactive T cells
AU - Holmdahl, Rikard
AU - Sareila, Outi
AU - Pizzolla, Angela
AU - Winter, Susann
AU - Hagert, Cecilia
AU - Jaakkola, Noora
AU - Kelkka, Tiina
AU - Olsson, Lina M
AU - Wing, Kajsa
AU - Backdahl, Liselotte
PY - 2013
Y1 - 2013
N2 - Significance: An unexpected finding, revealed by positional cloning of genetic polymorphisms controlling models for rheumatoid arthritis, exposed a new function of Ncf1 and NADPH oxidase (NOX) 2 controlled oxidative burst. Recent Advances: A decreased capacity to produce ROS due to a natural polymorphism was found to be the major factor leading to more severe arthritis and increased T cell-dependent autoimmunity. Critical Issues: In the vein of this finding, we here review a possible new role of ROS in regulating inflammatory cell and autoreactive T cell activity. It is postulated that peroxide is an immunologic transmitter secreted by antigen-presenting cells that downregulate the responses by autoreactive T cells. Future Directions: This may operate at different levels of T cell selection and activation: during negative selection in the thymus, priming of T cells in draining lymph nodes, and while interacting with macrophages in peripheral target tissues. Antioxid. Redox Signal. 00, 000a??000.
AB - Significance: An unexpected finding, revealed by positional cloning of genetic polymorphisms controlling models for rheumatoid arthritis, exposed a new function of Ncf1 and NADPH oxidase (NOX) 2 controlled oxidative burst. Recent Advances: A decreased capacity to produce ROS due to a natural polymorphism was found to be the major factor leading to more severe arthritis and increased T cell-dependent autoimmunity. Critical Issues: In the vein of this finding, we here review a possible new role of ROS in regulating inflammatory cell and autoreactive T cell activity. It is postulated that peroxide is an immunologic transmitter secreted by antigen-presenting cells that downregulate the responses by autoreactive T cells. Future Directions: This may operate at different levels of T cell selection and activation: during negative selection in the thymus, priming of T cells in draining lymph nodes, and while interacting with macrophages in peripheral target tissues. Antioxid. Redox Signal. 00, 000a??000.
UR - http://online.liebertpub.com/doi/pdf/10.1089/ars.2012.4734
U2 - 10.1089/ars.2012.4734
DO - 10.1089/ars.2012.4734
M3 - Article
SN - 1523-0864
VL - 18
SP - 1463
EP - 1474
JO - Antioxidants and Redox Signaling
JF - Antioxidants and Redox Signaling
IS - 12
ER -