TY - JOUR
T1 - Hybrid nanomaterials that mimic the food effect: controlling enzymatic digestion for enhanced oral drug absorption
AU - Tan, Angel
AU - Martin, Amanda L
AU - Nguyen, Tri-Hung
AU - Boyd, Benjamin James
AU - Prestidge, Clive Allan
PY - 2012
Y1 - 2012
N2 - The effect of particle size on lipid
digestibility and drug absorption is a controversial topic;
some studies showed increased lipid digestibility and drug
bioavailability with reduced carrier particle sizes,[8] while
others reported negligible enhancement.[9] The extent of the
food effect contributed by various lipid-dosage forms has
been ambiguously drug-specific and mostly unpredictable.[10]
This unpredictability represents the greatest barrier for
successful translation of these systems from the bench-top
to the clinic.
AB - The effect of particle size on lipid
digestibility and drug absorption is a controversial topic;
some studies showed increased lipid digestibility and drug
bioavailability with reduced carrier particle sizes,[8] while
others reported negligible enhancement.[9] The extent of the
food effect contributed by various lipid-dosage forms has
been ambiguously drug-specific and mostly unpredictable.[10]
This unpredictability represents the greatest barrier for
successful translation of these systems from the bench-top
to the clinic.
UR - http://onlinelibrary.wiley.com/doi/10.1002/anie.201200409/pdf
U2 - 10.1002/anie.201200409
DO - 10.1002/anie.201200409
M3 - Article
VL - 51
SP - 5475
EP - 5479
JO - Angewandte Chemie - International Edition
JF - Angewandte Chemie - International Edition
SN - 1433-7851
IS - 22
ER -