Hybrid nanomaterials that mimic the food effect: controlling enzymatic digestion for enhanced oral drug absorption

Angel Tan, Amanda L Martin, Tri-Hung Nguyen, Benjamin James Boyd, Clive Allan Prestidge

Research output: Contribution to journalArticleResearchpeer-review

45 Citations (Scopus)

Abstract

The effect of particle size on lipid digestibility and drug absorption is a controversial topic; some studies showed increased lipid digestibility and drug bioavailability with reduced carrier particle sizes,[8] while others reported negligible enhancement.[9] The extent of the food effect contributed by various lipid-dosage forms has been ambiguously drug-specific and mostly unpredictable.[10] This unpredictability represents the greatest barrier for successful translation of these systems from the bench-top to the clinic.
Original languageEnglish
Pages (from-to)5475 - 5479
Number of pages5
JournalAngewandte Chemie - International Edition
Volume51
Issue number22
DOIs
Publication statusPublished - 2012

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