Hybrid-collimator design for a small animal imager: PEDRO

Chuong V. Nguyen, Jeremy M.C. Brown, Rob A. Lewis, David V. Martin, Matthew R. Dimmock, Dmitri A. Nikulin, John E. Gillam

    Research output: Chapter in Book/Report/Conference proceedingConference PaperResearchpeer-review

    Abstract

    The Pixelated Emission Detector for RadiOisotopes (PEDRO) is a hybrid imaging system designed for the measurement of single photon emission from small animal models. The proof-of-principle device consists of a Compton-camera situated behind a mechanical collimator and is intended to provide optimal detection characteristics over a broad spectral range, from 30 keV to 511 keV. An automated routine has been developed for the optimization of the mechanical collimator which consists of pinholes and open slits. The optimization was tested with a Geant4 model of the experimental prototype. The data were blurred with the expected position and energy resolution parameters and a Bayesian interaction ordering algorithm was applied. The results show that the optimization technique allows the large-area slits to sample fully the primary field of view (FoV). The slits were found to provide truncation of the back-projected cones of response and also an increase in the success rate of the interaction ordering algorithm. These factors resulted in an increase in the contrast and signal-to-noise ratios of the reconstructed image estimates.

    Original languageEnglish
    Title of host publicationIEEE Nuclear Science Symposuim and Medical Imaging Conference, NSS/MIC 2010
    Pages3042-3048
    Number of pages7
    DOIs
    Publication statusPublished - 2010
    EventIEEE Nuclear Science Symposium and Medical Imaging Conference 2010 - Knoxville, United States of America
    Duration: 30 Oct 20106 Nov 2010

    Conference

    ConferenceIEEE Nuclear Science Symposium and Medical Imaging Conference 2010
    Abbreviated titleNSS/MIC 2010
    CountryUnited States of America
    CityKnoxville
    Period30/10/106/11/10
    Other2010 IEEE Nuclear Science Symposium, Medical Imaging Conference, NSS/MIC 2010 and 17th International Workshop on Room-Temperature Semiconductor X-ray and Gamma-ray Detectors, RTSD 2010

    Keywords

    • Compton scattering enhancement
    • multiple pinhole
    • PEDRO

    Cite this

    Nguyen, C. V., Brown, J. M. C., Lewis, R. A., Martin, D. V., Dimmock, M. R., Nikulin, D. A., & Gillam, J. E. (2010). Hybrid-collimator design for a small animal imager: PEDRO. In IEEE Nuclear Science Symposuim and Medical Imaging Conference, NSS/MIC 2010 (pp. 3042-3048). [5874358] https://doi.org/10.1109/NSSMIC.2010.5874358