Hybrid approaches to molecular simulation

Bosco K Ho, David Perahia, Ashley M Buckle

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Abstract

Molecular dynamics (MD) simulation is an established method for studying the conformational changes that are important for protein function. Recent advances in hardware and software have allowed MD simulations over the same timescales as experiment, improving the agreement between theory and experiment to a large extent. However, running such simulations are costly, in terms of resources, storage, and trajectory analysis. There is still a place for techniques that involve short MD simulations. In order to overcome the sampling paucity of short time-scales, hybrid methods that include some form of MD simulation can exploit certain features of the system of interest, often combining experimental information in surprising ways. Here, we review some recent hybrid approaches to the simulation of proteins.
Original languageEnglish
Pages (from-to)386 - 393
Number of pages8
JournalCurrent Opinion in Structural Biology
Volume22
Issue number3
DOIs
Publication statusPublished - 2012

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