TY - JOUR
T1 - Hyaluronic acid-functionalized lipoplexes and polyplexes as emerging nanocarriers for receptor-targeted cancer therapy
AU - Chandra, Jyoti
AU - Molugulu, Nagashekhara
AU - Annadurai, Sivakumar
AU - Wahab, Shadma
AU - Karwasra, Ritu
AU - Singh, Surender
AU - Shukla, Rahul
AU - Kesharwani, Prashant
N1 - Funding Information:
The authors (Sivakumar Annadurai and Shadma Wahab) extend their appreciation to the Deanship of Scientific Research at King Khalid University for funding this work through Small group Research Project under grant number RGP1/220/44 .
Publisher Copyright:
© 2023 Elsevier Inc.
PY - 2023/9/15
Y1 - 2023/9/15
N2 - Cancer is an intricate disease that develops as a response to a combination of hereditary and environmental risk factors, which then result in a variety of changes to the genome. The cluster of differentiation (CD44) is a type of transmembrane glycoprotein that serves as a potential biomarker for cancer stem cells (CSC) and viable targets for therapeutic intervention in the context of cancer therapy. Hyaluronic acid (HA) is a linear polysaccharide that exhibits a notable affinity for the CD44 receptor. This characteristic renders it a promising candidate for therapeutic interventions aimed at selectively targeting CD44-positive cancer cells. Treating cancer via non-viral vector-based gene delivery has changed the notion of curing illness through the incorporation of therapeutic genes into the organism. The objective of this review is to provide an overview of various hyaluronic acid-modified lipoplexes and polyplexes as potential drug delivery methods for specific forms of cancer by effectively targeting CD44.
AB - Cancer is an intricate disease that develops as a response to a combination of hereditary and environmental risk factors, which then result in a variety of changes to the genome. The cluster of differentiation (CD44) is a type of transmembrane glycoprotein that serves as a potential biomarker for cancer stem cells (CSC) and viable targets for therapeutic intervention in the context of cancer therapy. Hyaluronic acid (HA) is a linear polysaccharide that exhibits a notable affinity for the CD44 receptor. This characteristic renders it a promising candidate for therapeutic interventions aimed at selectively targeting CD44-positive cancer cells. Treating cancer via non-viral vector-based gene delivery has changed the notion of curing illness through the incorporation of therapeutic genes into the organism. The objective of this review is to provide an overview of various hyaluronic acid-modified lipoplexes and polyplexes as potential drug delivery methods for specific forms of cancer by effectively targeting CD44.
KW - Cancer stem cell
KW - CD44
KW - Gene delivery
KW - Lipoplexes
KW - Polyplexes
UR - http://www.scopus.com/inward/record.url?scp=85163882767&partnerID=8YFLogxK
U2 - 10.1016/j.envres.2023.116506
DO - 10.1016/j.envres.2023.116506
M3 - Review Article
C2 - 37369307
AN - SCOPUS:85163882767
SN - 0013-9351
VL - 233
JO - Environmental Research
JF - Environmental Research
M1 - 116506
ER -
