@article{721bc449648d480083d4859181794a6c,
title = "Hyaluronic acid-based nanoplatforms for Doxorubicin: A review of stimuli-responsive carriers, co-delivery and resistance suppression",
abstract = "An important motivation for the use of nanomaterials and nanoarchitectures in cancer therapy emanates from the widespread emergence of drug resistance. Although doxorubicin (DOX) induces cell cycle arrest and DNA damage by suppressing topoisomerase activity, resistance to DOX has severely restricted its anti-cancer potential. Hyaluronic acid (HA) has been extensively utilized for synthesizing nanoparticles as it interacts with CD44 expressed on the surface of cancer cells. Cancer cells can take up HA-modified nanoparticles through receptor-mediated endocytosis. Various types of nanostructures such as carbon nanomaterials, lipid nanoparticles and polymeric nanocarriers have been modified with HA to enhance the delivery of DOX to cancer cells. Hyaluronic acid-based advanced materials provide a platform for the co-delivery of genes and drugs along with DOX to enhance the efficacy of anti-cancer therapy and overcome chemoresistance. In the present review, the potential methods and application of HA-modified nanostructures for DOX delivery in anti-cancer therapy are discussed.",
keywords = "CD44, Doxorubicin, Drug resistance, Endocytosis, Hyaluronic acid, Nanodelivery system, Theranostic",
author = "Milad Ashrafizadeh and Sepideh Mirzaei and Gholami, {Mohammad Hossein} and Farid Hashemi and Amirhossein Zabolian and Mehdi Raei and Kiavash Hushmandi and Ali Zarrabi and Voelcker, {Nicolas H.} and Aref, {Amir Reza} and Hamblin, {Michael R.} and Varma, {Rajender S.} and Saeed Samarghandian and Arostegi, {I. J.} and M. Alzola and Kumar, {Alan Prem} and Thakur, {Vijay Kumar} and Noushin Nabavi and Pooyan Makvandi and Tay, {Franklin R.} and Gorka Orive",
note = "Funding Information: Grant from the Ministry of Education - Singapore ( MOE-T2EP30120-0016 ) supported APK. The National Research Foundation Singapore and the Singapore Ministry of Education under its Research Center of Excellence initiative to Cancer Science Institute of Singapore ; National University of Singapore also supported APK. GO wish to thank the Spanish Ministry of Economy, Industry, and Competitiveness (SAF2016-76150-R and BFU2017-82421-P) and technical assistance from the ICTS NANBIOSIS (Drug Formulation Unit, U10) at the University of the Basque Country. Figs. 1 and 2 were drawn by Biorender (Biorender.com). Publisher Copyright: {\textcopyright} 2021 The Author(s) Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",
year = "2021",
month = nov,
day = "15",
doi = "10.1016/j.carbpol.2021.118491",
language = "English",
volume = "272",
journal = "Carbohydrate Polymers",
issn = "0144-8617",
publisher = "Elsevier",
}
