Hyaluronic acid-based conjugates for tumor-targeted drug delivery and imaging

Gurusamy Saravanakumar, V. G. Deepagan, R. Jayakumar, Jae Hyung Park

Research output: Contribution to journalReview ArticleResearchpeer-review

33 Citations (Scopus)

Abstract

In recent years, hyaluronic acid (HA) has attracted significant interest in development of drug delivery systems because of its intrinsic physicochemical and biological properties, including water solubility, viscoeleasticity, non-immunogenicity, biocompatibility, and biodegradability. In addition, HA has the ability to selectively bind specific receptors on the disease-related cells such as cancer cells and activated macrophages, followed by receptor-mediated endocytosis. Owing to these unique features, HA has been extensively used for development of the targetable carriers to deliver the therapeutic and imaging agents. In this review, we discuss the recent progress in various HA-based conjugates for cancer therapy and imaging, in which the active agents are covalently conjugated or physically encapsulated.

Original languageEnglish
Pages (from-to)17-31
Number of pages15
JournalJournal of Biomedical Nanotechnology
Volume10
Issue number1
DOIs
Publication statusPublished - 1 Jan 2014
Externally publishedYes

Keywords

  • Conjugate
  • Drug delivery
  • Hyaluronic acid
  • Imaging agent

Cite this