Huntington’s disease

Phyllis Chua, Samantha Loi, Edmond Chiu

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1 Citation (Scopus)


Huntington’s disease (HD) is an autosomal-dominant progressive neurodegenerative disorder beginning classically in midlife with the characteristic triad of motor, cognitive and psychiatric symptoms. Within this characteristic triad, there is variety in the clinical phenotype with respect to timing of onset, symptoms and progression. Death usually occurs 20-30 years aer the onset of motor symptoms. Discovery of the HD gene in 1993 has changed our understanding of the natural history of HD with recognition of preclinical manifestations and early symptoms prior to the classical motor manifestations.

Original languageEnglish
Title of host publicationDementia
EditorsDavid Ames, John O’Brien, Alistair Burns
Place of PublicationBoca Raton
PublisherCRC Press
Number of pages17
ISBN (Electronic)9781498703116
ISBN (Print)9781498703123
Publication statusPublished - 1 Jan 2017

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