Huntington’s disease

Phyllis Chua; Samantha Loi; Edmond Chiu

Huntington’s disease

Phyllis Chua, Samantha Loi, Edmond Chiu

Psychiatry Monash Health

Research output: Chapter in Book/Report/Conference proceeding › Chapter (Book) › Other › peer-review

2 Citations (Scopus)

Abstract

Huntington’s disease (HD) is an autosomal-dominant progressive neurodegenerative disorder beginning classically in midlife with the characteristic triad of motor, cognitive and psychiatric symptoms. Within this characteristic triad, there is variety in the clinical phenotype with respect to timing of onset, symptoms and progression. Death usually occurs 20-30 years aer the onset of motor symptoms. Discovery of the HD gene in 1993 has changed our understanding of the natural history of HD with recognition of preclinical manifestations and early symptoms prior to the classical motor manifestations.

Original language	English
Title of host publication	Dementia
Editors	David Ames, John O’Brien, Alistair Burns
Place of Publication	Boca Raton
Publisher	CRC Press
Chapter	76
Pages	868-884
Number of pages	17
Edition	5th
ISBN (Electronic)	9781498703116
ISBN (Print)	9781498703123
Publication status	Published - 1 Jan 2017

Cite this

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title = "Huntington{\textquoteright}s disease",

abstract = "Huntington{\textquoteright}s disease (HD) is an autosomal-dominant progressive neurodegenerative disorder beginning classically in midlife with the characteristic triad of motor, cognitive and psychiatric symptoms. Within this characteristic triad, there is variety in the clinical phenotype with respect to timing of onset, symptoms and progression. Death usually occurs 20-30 years aer the onset of motor symptoms. Discovery of the HD gene in 1993 has changed our understanding of the natural history of HD with recognition of preclinical manifestations and early symptoms prior to the classical motor manifestations.",

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AU - Loi, Samantha

AU - Chiu, Edmond

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AB - Huntington’s disease (HD) is an autosomal-dominant progressive neurodegenerative disorder beginning classically in midlife with the characteristic triad of motor, cognitive and psychiatric symptoms. Within this characteristic triad, there is variety in the clinical phenotype with respect to timing of onset, symptoms and progression. Death usually occurs 20-30 years aer the onset of motor symptoms. Discovery of the HD gene in 1993 has changed our understanding of the natural history of HD with recognition of preclinical manifestations and early symptoms prior to the classical motor manifestations.

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M3 - Chapter (Book)

AN - SCOPUS:85052196962

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A2 - Ames, David

A2 - O’Brien, John

A2 - Burns, Alistair

PB - CRC Press

CY - Boca Raton

ER -

Huntington’s disease

Abstract

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Cite this