TY - JOUR
T1 - Humoral factors in intestinal adaption
AU - Baksheev, Lyrissa
AU - Fuller, Peter J.
PY - 2000
Y1 - 2000
N2 - The small bowel has a remarkable ability to adapt after injury, inflammation or resection. It has long been suggested that humoral factors, particularly enteroglucagon, epidermal growth factor, neurotensin and growth hormone/insulin-like growth factor I, might stimulate bowel growth. Of particular interest is the recent finding that glucagon-like peptide 2 (GLP-2), a product of the gene encoding proglucagon, exerts a trophic effect on the intestinal epithelium via a specific G-protein-coupled receptor. GLP-2 and/or these other trophic peptides might prove to have a role in the treatment of bowel diseases associated with structural or functional loss of the small bowel.
AB - The small bowel has a remarkable ability to adapt after injury, inflammation or resection. It has long been suggested that humoral factors, particularly enteroglucagon, epidermal growth factor, neurotensin and growth hormone/insulin-like growth factor I, might stimulate bowel growth. Of particular interest is the recent finding that glucagon-like peptide 2 (GLP-2), a product of the gene encoding proglucagon, exerts a trophic effect on the intestinal epithelium via a specific G-protein-coupled receptor. GLP-2 and/or these other trophic peptides might prove to have a role in the treatment of bowel diseases associated with structural or functional loss of the small bowel.
UR - http://www.scopus.com/inward/record.url?scp=0033670507&partnerID=8YFLogxK
U2 - 10.1016/S1043-2760(00)00307-6
DO - 10.1016/S1043-2760(00)00307-6
M3 - Review Article
C2 - 11091116
AN - SCOPUS:0033670507
SN - 1043-2760
VL - 11
SP - 401
EP - 405
JO - Trends in Endocrinology & Metabolism
JF - Trends in Endocrinology & Metabolism
IS - 10
ER -