Humoral factors in intestinal adaption

Lyrissa Baksheev, Peter J. Fuller

Research output: Contribution to journalReview ArticleResearchpeer-review

28 Citations (Scopus)


The small bowel has a remarkable ability to adapt after injury, inflammation or resection. It has long been suggested that humoral factors, particularly enteroglucagon, epidermal growth factor, neurotensin and growth hormone/insulin-like growth factor I, might stimulate bowel growth. Of particular interest is the recent finding that glucagon-like peptide 2 (GLP-2), a product of the gene encoding proglucagon, exerts a trophic effect on the intestinal epithelium via a specific G-protein-coupled receptor. GLP-2 and/or these other trophic peptides might prove to have a role in the treatment of bowel diseases associated with structural or functional loss of the small bowel.

Original languageEnglish
Pages (from-to)401-405
Number of pages5
JournalTrends in Endocrinology & Metabolism
Issue number10
Publication statusPublished - 2000
Externally publishedYes

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