Humanized Mice for Modeling Human Infectious Disease: Challenges, Progress, and Outlook

Nicolas Legrand, Alexander Ploss, Rudi Balling, Pablo D. Becker, Chiara Borsotti, Nicolas Brezillon, Jennifer Debarry, Ype de Jong, Hongkui Deng, James P. Di Santo, Stephanie Eisenbarth, Elizabeth Eynon, Richard A. Flavell, Carlos A. Guzman, Nicholas D. Huntington, Dina Kremsdorf, Michael P. Manns, Markus G. Manz, Jean Jacques Mention, Michael OttChozhavendan Rathinam, Charles M. Rice, Anthony Rongvaux, Sean Stevens, Hergen Spits, Hélène Strick-Marchand, Hitoshi Takizawa, Anja U. van Lent, Chengyan Wang, Kees Weijer, Tim Willinger, Patrick Ziegler

Research output: Contribution to journalShort SurveyResearchpeer-review

179 Citations (Scopus)


Over 800 million people worldwide are infected with hepatitis viruses, human immunodeficiency virus (HIV), and malaria, resulting in more than 5 million deaths annually. Here we discuss the potential and challenges of humanized mouse models for developing effective and affordable therapies and vaccines, which are desperately needed to combat these diseases.

Original languageEnglish
Pages (from-to)5-9
Number of pages5
JournalCell Host & Microbe
Issue number1
Publication statusPublished - 23 Jul 2009
Externally publishedYes

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