Humanized Mice for Modeling Human Infectious Disease: Challenges, Progress, and Outlook

Nicolas Legrand; Alexander Ploss; Rudi Balling; Pablo D. Becker; Chiara Borsotti; Nicolas Brezillon; Jennifer Debarry; Ype de Jong; Hongkui Deng; James P. Di Santo; Stephanie Eisenbarth; Elizabeth Eynon; Richard A. Flavell; Carlos A. Guzman; Nicholas D. Huntington; Dina Kremsdorf; Michael P. Manns; Markus G. Manz; Jean Jacques Mention; Michael Ott; Chozhavendan Rathinam; Charles M. Rice; Anthony Rongvaux; Sean Stevens; Hergen Spits; Hélène Strick-Marchand; Hitoshi Takizawa; Anja U. van Lent; Chengyan Wang; Kees Weijer; Tim Willinger; Patrick Ziegler

doi:10.1016/j.chom.2009.06.006

Humanized Mice for Modeling Human Infectious Disease: Challenges, Progress, and Outlook

Nicolas Legrand, Alexander Ploss, Rudi Balling, Pablo D. Becker, Chiara Borsotti, Nicolas Brezillon, Jennifer Debarry, Ype de Jong, Hongkui Deng, James P. Di Santo, Stephanie Eisenbarth, Elizabeth Eynon, Richard A. Flavell, Carlos A. Guzman, Nicholas D. Huntington, Dina Kremsdorf, Michael P. Manns, Markus G. Manz, Jean Jacques Mention, Michael OttChozhavendan Rathinam, Charles M. Rice, Anthony Rongvaux, Sean Stevens, Hergen Spits, Hélène Strick-Marchand, Hitoshi Takizawa, Anja U. van Lent, Chengyan Wang, Kees Weijer, Tim Willinger, Patrick Ziegler

Research output: Contribution to journal › Short Survey › Research › peer-review

184 Citations (Scopus)

Abstract

Over 800 million people worldwide are infected with hepatitis viruses, human immunodeficiency virus (HIV), and malaria, resulting in more than 5 million deaths annually. Here we discuss the potential and challenges of humanized mouse models for developing effective and affordable therapies and vaccines, which are desperately needed to combat these diseases.

Original language	English
Pages (from-to)	5-9
Number of pages	5
Journal	Cell Host & Microbe
Volume	6
Issue number	1
DOIs	https://doi.org/10.1016/j.chom.2009.06.006
Publication status	Published - 23 Jul 2009
Externally published	Yes

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.chom.2009.06.006

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Legrand, N., Ploss, A., Balling, R., Becker, P. D., Borsotti, C., Brezillon, N., Debarry, J., de Jong, Y., Deng, H., Di Santo, J. P., Eisenbarth, S., Eynon, E., Flavell, R. A., Guzman, C. A., Huntington, N. D., Kremsdorf, D., Manns, M. P., Manz, M. G., Mention, J. J., ... Ziegler, P. (2009). Humanized Mice for Modeling Human Infectious Disease: Challenges, Progress, and Outlook. Cell Host & Microbe, 6(1), 5-9. https://doi.org/10.1016/j.chom.2009.06.006

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title = "Humanized Mice for Modeling Human Infectious Disease: Challenges, Progress, and Outlook",

abstract = "Over 800 million people worldwide are infected with hepatitis viruses, human immunodeficiency virus (HIV), and malaria, resulting in more than 5 million deaths annually. Here we discuss the potential and challenges of humanized mouse models for developing effective and affordable therapies and vaccines, which are desperately needed to combat these diseases.",

author = "Nicolas Legrand and Alexander Ploss and Rudi Balling and Becker, {Pablo D.} and Chiara Borsotti and Nicolas Brezillon and Jennifer Debarry and {de Jong}, Ype and Hongkui Deng and {Di Santo}, {James P.} and Stephanie Eisenbarth and Elizabeth Eynon and Flavell, {Richard A.} and Guzman, {Carlos A.} and Huntington, {Nicholas D.} and Dina Kremsdorf and Manns, {Michael P.} and Manz, {Markus G.} and Mention, {Jean Jacques} and Michael Ott and Chozhavendan Rathinam and Rice, {Charles M.} and Anthony Rongvaux and Sean Stevens and Hergen Spits and H{\'e}l{\`e}ne Strick-Marchand and Hitoshi Takizawa and {van Lent}, {Anja U.} and Chengyan Wang and Kees Weijer and Tim Willinger and Patrick Ziegler",

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doi = "10.1016/j.chom.2009.06.006",

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Legrand, N, Ploss, A, Balling, R, Becker, PD, Borsotti, C, Brezillon, N, Debarry, J, de Jong, Y, Deng, H, Di Santo, JP, Eisenbarth, S, Eynon, E, Flavell, RA, Guzman, CA, Huntington, ND, Kremsdorf, D, Manns, MP, Manz, MG, Mention, JJ, Ott, M, Rathinam, C, Rice, CM, Rongvaux, A, Stevens, S, Spits, H, Strick-Marchand, H, Takizawa, H, van Lent, AU, Wang, C, Weijer, K, Willinger, T & Ziegler, P 2009, 'Humanized Mice for Modeling Human Infectious Disease: Challenges, Progress, and Outlook', Cell Host & Microbe, vol. 6, no. 1, pp. 5-9. https://doi.org/10.1016/j.chom.2009.06.006

TY - JOUR

T1 - Humanized Mice for Modeling Human Infectious Disease

T2 - Challenges, Progress, and Outlook

AU - Legrand, Nicolas

AU - Ploss, Alexander

AU - Balling, Rudi

AU - Becker, Pablo D.

AU - Borsotti, Chiara

AU - Brezillon, Nicolas

AU - Debarry, Jennifer

AU - de Jong, Ype

AU - Deng, Hongkui

AU - Di Santo, James P.

AU - Eisenbarth, Stephanie

AU - Eynon, Elizabeth

AU - Flavell, Richard A.

AU - Guzman, Carlos A.

AU - Huntington, Nicholas D.

AU - Kremsdorf, Dina

AU - Manns, Michael P.

AU - Manz, Markus G.

AU - Mention, Jean Jacques

AU - Ott, Michael

AU - Rathinam, Chozhavendan

AU - Rice, Charles M.

AU - Rongvaux, Anthony

AU - Stevens, Sean

AU - Spits, Hergen

AU - Strick-Marchand, Hélène

AU - Takizawa, Hitoshi

AU - van Lent, Anja U.

AU - Wang, Chengyan

AU - Weijer, Kees

AU - Willinger, Tim

AU - Ziegler, Patrick

PY - 2009/7/23

Y1 - 2009/7/23

N2 - Over 800 million people worldwide are infected with hepatitis viruses, human immunodeficiency virus (HIV), and malaria, resulting in more than 5 million deaths annually. Here we discuss the potential and challenges of humanized mouse models for developing effective and affordable therapies and vaccines, which are desperately needed to combat these diseases.

AB - Over 800 million people worldwide are infected with hepatitis viruses, human immunodeficiency virus (HIV), and malaria, resulting in more than 5 million deaths annually. Here we discuss the potential and challenges of humanized mouse models for developing effective and affordable therapies and vaccines, which are desperately needed to combat these diseases.

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U2 - 10.1016/j.chom.2009.06.006

DO - 10.1016/j.chom.2009.06.006

M3 - Short Survey

C2 - 19616761

AN - SCOPUS:67651102866

SN - 1931-3128

VL - 6

SP - 5

EP - 9

JO - Cell Host & Microbe

JF - Cell Host & Microbe

IS - 1

ER -

Humanized Mice for Modeling Human Infectious Disease: Challenges, Progress, and Outlook

Abstract

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