Human to mosquito transmission of dengue viruses

Lauren B. Carrington, Cameron P. Simmons

Research output: Contribution to journalReview ArticleResearchpeer-review

93 Citations (Scopus)

Abstract

The successful transmission of dengue virus from a human host to a mosquito vector requires a complex set of factors to align. It is becoming increasingly important to improve our understanding of the parameters that shape the human to mosquito component of the transmission cycle so that vaccines and therapeutic antivirals can be fully evaluated and epidemiological models refined. Here we describe these factors, and discuss the biological and environmental impacts and demographic changes that are influencing these dynamics. Specifically, we examine features of the human infection required for the mosquito to acquire the virus via natural blood feeding, as well as the biological and environmental factors that influence a mosquito's susceptibility to infection, up to the point that they are capable of transmitting the virus to a new host.

Original languageEnglish
Article number290
Number of pages8
JournalFrontiers in Immunology
Volume5
Issue numberJUN
DOIs
Publication statusPublished - 2014
Externally publishedYes

Keywords

  • Aedes aegypti
  • Aedes albopictus
  • Dengue virus
  • Symptomatic vs. asymptomatic infections
  • Temperature
  • Transmission
  • Viral titer

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