Human prostate-specific antigen (Aps) is a member of the glandular kallikrein gene family at 19q13

G. R. Sutherland; E. Baker; V. J. Hyland; D. F. Callen; J. A. Close; G. W. Tregear; B. A. Evans; R. I. Richards

doi:10.1159/000132629

Human prostate-specific antigen (Aps) is a member of the glandular kallikrein gene family at 19q13

G. R. Sutherland
, E. Baker
, V. J. Hyland
, D. F. Callen
, J. A. Close
, G. W. Tregear
, B. A. Evans
, R. I. Richards

Research output: Contribution to journal › Article › Research › peer-review

35 Citations (Scopus)

Abstract

The amino acid sequence of human prostate-specific antigen (APS) suggests that it is a member of the glandular kallikrein subfamily of serine proteases. In the mouse, the kallikrein* like family is localized in a single locus on chromosome 7. While other serine proteases are distributed over a variety of different chromosomes. To investigate the physical relationship between the human kallikrein genes, we have used in situ hybridization and Southern analysis of a human x mouse somatic cell hybrid panel to map the APS gene to 19q 13, concordant with the renal kallikrein KLKI gene. This finding indicates that APS is a member of a human kallikrein-like gene family with analogous organization to that of the mouse.

Original language	English
Pages (from-to)	205-207
Number of pages	3
Journal	Cytogenetic and Genome Research
Volume	48
Issue number	4
DOIs	https://doi.org/10.1159/000132629
Publication status	Published - 1 Jan 1988
Externally published	Yes

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title = "Human prostate-specific antigen (Aps) is a member of the glandular kallikrein gene family at 19q13",

abstract = "The amino acid sequence of human prostate-specific antigen (APS) suggests that it is a member of the glandular kallikrein subfamily of serine proteases. In the mouse, the kallikrein* like family is localized in a single locus on chromosome 7. While other serine proteases are distributed over a variety of different chromosomes. To investigate the physical relationship between the human kallikrein genes, we have used in situ hybridization and Southern analysis of a human x mouse somatic cell hybrid panel to map the APS gene to 19q 13, concordant with the renal kallikrein KLKI gene. This finding indicates that APS is a member of a human kallikrein-like gene family with analogous organization to that of the mouse.",

author = "Sutherland, \{G. R.\} and E. Baker and Hyland, \{V. J.\} and Callen, \{D. F.\} and Close, \{J. A.\} and Tregear, \{G. W.\} and Evans, \{B. A.\} and Richards, \{R. I.\}",

year = "1988",

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T1 - Human prostate-specific antigen (Aps) is a member of the glandular kallikrein gene family at 19q13

AU - Sutherland, G. R.

AU - Baker, E.

AU - Hyland, V. J.

AU - Callen, D. F.

AU - Close, J. A.

AU - Tregear, G. W.

AU - Evans, B. A.

AU - Richards, R. I.

PY - 1988/1/1

Y1 - 1988/1/1

N2 - The amino acid sequence of human prostate-specific antigen (APS) suggests that it is a member of the glandular kallikrein subfamily of serine proteases. In the mouse, the kallikrein* like family is localized in a single locus on chromosome 7. While other serine proteases are distributed over a variety of different chromosomes. To investigate the physical relationship between the human kallikrein genes, we have used in situ hybridization and Southern analysis of a human x mouse somatic cell hybrid panel to map the APS gene to 19q 13, concordant with the renal kallikrein KLKI gene. This finding indicates that APS is a member of a human kallikrein-like gene family with analogous organization to that of the mouse.

AB - The amino acid sequence of human prostate-specific antigen (APS) suggests that it is a member of the glandular kallikrein subfamily of serine proteases. In the mouse, the kallikrein* like family is localized in a single locus on chromosome 7. While other serine proteases are distributed over a variety of different chromosomes. To investigate the physical relationship between the human kallikrein genes, we have used in situ hybridization and Southern analysis of a human x mouse somatic cell hybrid panel to map the APS gene to 19q 13, concordant with the renal kallikrein KLKI gene. This finding indicates that APS is a member of a human kallikrein-like gene family with analogous organization to that of the mouse.

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DO - 10.1159/000132629

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JO - Cytogenetic and Genome Research

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IS - 4

ER -

Human prostate-specific antigen (Aps) is a member of the glandular kallikrein gene family at 19q13

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