Human prostate-specific antigen (Aps) is a member of the glandular kallikrein gene family at 19q13

G. R. Sutherland, E. Baker, V. J. Hyland, D. F. Callen, J. A. Close, G. W. Tregear, B. A. Evans, R. I. Richards

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Abstract

The amino acid sequence of human prostate-specific antigen (APS) suggests that it is a member of the glandular kallikrein subfamily of serine proteases. In the mouse, the kallikrein* like family is localized in a single locus on chromosome 7. While other serine proteases are distributed over a variety of different chromosomes. To investigate the physical relationship between the human kallikrein genes, we have used in situ hybridization and Southern analysis of a human x mouse somatic cell hybrid panel to map the APS gene to 19q 13, concordant with the renal kallikrein KLKI gene. This finding indicates that APS is a member of a human kallikrein-like gene family with analogous organization to that of the mouse.

Original languageEnglish
Pages (from-to)205-207
Number of pages3
JournalCytogenetic and Genome Research
Volume48
Issue number4
DOIs
Publication statusPublished - 1 Jan 1988
Externally publishedYes

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