Human pluripotent stem cell strategies for age-related macular degeneration

Kathryn C. Davidson, Robyn H. Guymer, Martin F. Pera, Alice Pébay

Research output: Contribution to journalReview ArticleOtherpeer-review

5 Citations (Scopus)

Abstract

Age-related macular degeneration (AMD) is a leading cause of severe vision loss in the Western world and is increasing exponentially as the population ages. Despite enormous worldwide efforts, the earliest pathogenic pathways involved in AMD are still not fully understood. It is essential to develop research tools for effective modeling of AMD pathogenesis and for subsequent drug discovery and cell or molecular therapies. This review will focus on the current progress in human pluripotent stem cells for understanding and treating AMD.

Original languageEnglish
Pages (from-to)887-893
Number of pages7
JournalOptometry and Vision Science
Volume91
Issue number8
DOIs
Publication statusPublished - Aug 2014
Externally publishedYes

Keywords

  • Age-related macular degeneration
  • Cell transplantation
  • Disease modeling
  • Drug screening
  • Embryonic stem cells
  • Induced pluripotent stem cells

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