Abstract
Age-related macular degeneration (AMD) is a leading cause of severe vision loss in the Western world and is increasing exponentially as the population ages. Despite enormous worldwide efforts, the earliest pathogenic pathways involved in AMD are still not fully understood. It is essential to develop research tools for effective modeling of AMD pathogenesis and for subsequent drug discovery and cell or molecular therapies. This review will focus on the current progress in human pluripotent stem cells for understanding and treating AMD.
Original language | English |
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Pages (from-to) | 887-893 |
Number of pages | 7 |
Journal | Optometry and Vision Science |
Volume | 91 |
Issue number | 8 |
DOIs | |
Publication status | Published - Aug 2014 |
Externally published | Yes |
Keywords
- Age-related macular degeneration
- Cell transplantation
- Disease modeling
- Drug screening
- Embryonic stem cells
- Induced pluripotent stem cells