Human papillomavirus infection and associated factors for cervical intraepithelial neoplasia in women living with HIV in China

A cross-sectional study

Qian Wang, Xiaomeng Ma, Xiaosong Zhang, Jason J. Ong, Jun Jing, Lei Zhang, Lin Hong Wang

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Objective: Women living with HIV (WLHIV) face disproportionately higher risks of acquiring human papillomavirus (HPV) compared with HIV negative counterparts. We aimed to investigate the prevalence of HPV in WLHIV in Chinese hospital setting and identify associated factors to the progression of late-stage cervical intraepithelial neoplasia (CIN2+) in this population. Method: This retrospective study collected data from 183 WLHIV on antiretroviral treatment (ART), based on reproductive health questionnaires. Gynaecological examination results including serum (for HIV viral load, CD4 T-cell count, hepatitis B infections, syphilis) and vaginal swabs for common bacterial sexually transmitted infections (STIs). Multivariate-logistic regression was applied to analyze the contributing factors to CIN2+. Results: HIV coinfection with other Sexually Transmitted Infections (STIs) were observed in 99 participants (54.1%, (99/183)). HPV (43.7% (80/183)) was the most prevalent STI. The three most prevalent HPV subtypes were all high-risk HPV (HR-HPV), including HPV52 (33.8% (27/80)), HPV58 (21.3% (17/80)) and HPV33 (13.75% (11/80)). About a third (37.5%, 30/80) of women with HPV had HR-HPV. Multiple HPV coinfections were common in HIV-HPV coinfected women (41.3%, 33/80). Cytological examinations revealed that 77.5% (62/80) HPV+ women had detectable cervical lesions. In comparison, only 4.9% (5/103) HPV negative womenwith Atypia and 1.0% (1/103) with CIN1 were diagnosed. Multivariate logistic regression revealed that HPV16 (OR=19.04, 2.53 to 122.92; p=0.004) and HPV18 (OR=11.54, 1.45 to 91.64; p=0.021) infections were significantly associated with CIN2+ in HIV-HPV coinfected women. Conclusion: A high prevalence of HPV was found in women on ART. HPV16/18 infection are strong associated factors to CIN2+ in HIV-HPV coinfected women.

Original languageEnglish
Pages (from-to)140-144
Number of pages5
JournalSexually Transmitted Infections
Volume95
Issue number2
DOIs
Publication statusPublished - 1 Mar 2019

Keywords

  • cervical neoplasia
  • HIV
  • HPV
  • women

Cite this

@article{abc1a733fa5c411686e0d9e51a05306d,
title = "Human papillomavirus infection and associated factors for cervical intraepithelial neoplasia in women living with HIV in China: A cross-sectional study",
abstract = "Objective: Women living with HIV (WLHIV) face disproportionately higher risks of acquiring human papillomavirus (HPV) compared with HIV negative counterparts. We aimed to investigate the prevalence of HPV in WLHIV in Chinese hospital setting and identify associated factors to the progression of late-stage cervical intraepithelial neoplasia (CIN2+) in this population. Method: This retrospective study collected data from 183 WLHIV on antiretroviral treatment (ART), based on reproductive health questionnaires. Gynaecological examination results including serum (for HIV viral load, CD4 T-cell count, hepatitis B infections, syphilis) and vaginal swabs for common bacterial sexually transmitted infections (STIs). Multivariate-logistic regression was applied to analyze the contributing factors to CIN2+. Results: HIV coinfection with other Sexually Transmitted Infections (STIs) were observed in 99 participants (54.1{\%}, (99/183)). HPV (43.7{\%} (80/183)) was the most prevalent STI. The three most prevalent HPV subtypes were all high-risk HPV (HR-HPV), including HPV52 (33.8{\%} (27/80)), HPV58 (21.3{\%} (17/80)) and HPV33 (13.75{\%} (11/80)). About a third (37.5{\%}, 30/80) of women with HPV had HR-HPV. Multiple HPV coinfections were common in HIV-HPV coinfected women (41.3{\%}, 33/80). Cytological examinations revealed that 77.5{\%} (62/80) HPV+ women had detectable cervical lesions. In comparison, only 4.9{\%} (5/103) HPV negative womenwith Atypia and 1.0{\%} (1/103) with CIN1 were diagnosed. Multivariate logistic regression revealed that HPV16 (OR=19.04, 2.53 to 122.92; p=0.004) and HPV18 (OR=11.54, 1.45 to 91.64; p=0.021) infections were significantly associated with CIN2+ in HIV-HPV coinfected women. Conclusion: A high prevalence of HPV was found in women on ART. HPV16/18 infection are strong associated factors to CIN2+ in HIV-HPV coinfected women.",
keywords = "cervical neoplasia, HIV, HPV, women",
author = "Qian Wang and Xiaomeng Ma and Xiaosong Zhang and Ong, {Jason J.} and Jun Jing and Lei Zhang and Wang, {Lin Hong}",
year = "2019",
month = "3",
day = "1",
doi = "10.1136/sextrans-2018-053636",
language = "English",
volume = "95",
pages = "140--144",
journal = "Sexually Transmitted Infections",
issn = "1368-4973",
publisher = "BMJ Group",
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Human papillomavirus infection and associated factors for cervical intraepithelial neoplasia in women living with HIV in China : A cross-sectional study. / Wang, Qian; Ma, Xiaomeng; Zhang, Xiaosong; Ong, Jason J.; Jing, Jun; Zhang, Lei; Wang, Lin Hong.

In: Sexually Transmitted Infections, Vol. 95, No. 2, 01.03.2019, p. 140-144.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Human papillomavirus infection and associated factors for cervical intraepithelial neoplasia in women living with HIV in China

T2 - A cross-sectional study

AU - Wang, Qian

AU - Ma, Xiaomeng

AU - Zhang, Xiaosong

AU - Ong, Jason J.

AU - Jing, Jun

AU - Zhang, Lei

AU - Wang, Lin Hong

PY - 2019/3/1

Y1 - 2019/3/1

N2 - Objective: Women living with HIV (WLHIV) face disproportionately higher risks of acquiring human papillomavirus (HPV) compared with HIV negative counterparts. We aimed to investigate the prevalence of HPV in WLHIV in Chinese hospital setting and identify associated factors to the progression of late-stage cervical intraepithelial neoplasia (CIN2+) in this population. Method: This retrospective study collected data from 183 WLHIV on antiretroviral treatment (ART), based on reproductive health questionnaires. Gynaecological examination results including serum (for HIV viral load, CD4 T-cell count, hepatitis B infections, syphilis) and vaginal swabs for common bacterial sexually transmitted infections (STIs). Multivariate-logistic regression was applied to analyze the contributing factors to CIN2+. Results: HIV coinfection with other Sexually Transmitted Infections (STIs) were observed in 99 participants (54.1%, (99/183)). HPV (43.7% (80/183)) was the most prevalent STI. The three most prevalent HPV subtypes were all high-risk HPV (HR-HPV), including HPV52 (33.8% (27/80)), HPV58 (21.3% (17/80)) and HPV33 (13.75% (11/80)). About a third (37.5%, 30/80) of women with HPV had HR-HPV. Multiple HPV coinfections were common in HIV-HPV coinfected women (41.3%, 33/80). Cytological examinations revealed that 77.5% (62/80) HPV+ women had detectable cervical lesions. In comparison, only 4.9% (5/103) HPV negative womenwith Atypia and 1.0% (1/103) with CIN1 were diagnosed. Multivariate logistic regression revealed that HPV16 (OR=19.04, 2.53 to 122.92; p=0.004) and HPV18 (OR=11.54, 1.45 to 91.64; p=0.021) infections were significantly associated with CIN2+ in HIV-HPV coinfected women. Conclusion: A high prevalence of HPV was found in women on ART. HPV16/18 infection are strong associated factors to CIN2+ in HIV-HPV coinfected women.

AB - Objective: Women living with HIV (WLHIV) face disproportionately higher risks of acquiring human papillomavirus (HPV) compared with HIV negative counterparts. We aimed to investigate the prevalence of HPV in WLHIV in Chinese hospital setting and identify associated factors to the progression of late-stage cervical intraepithelial neoplasia (CIN2+) in this population. Method: This retrospective study collected data from 183 WLHIV on antiretroviral treatment (ART), based on reproductive health questionnaires. Gynaecological examination results including serum (for HIV viral load, CD4 T-cell count, hepatitis B infections, syphilis) and vaginal swabs for common bacterial sexually transmitted infections (STIs). Multivariate-logistic regression was applied to analyze the contributing factors to CIN2+. Results: HIV coinfection with other Sexually Transmitted Infections (STIs) were observed in 99 participants (54.1%, (99/183)). HPV (43.7% (80/183)) was the most prevalent STI. The three most prevalent HPV subtypes were all high-risk HPV (HR-HPV), including HPV52 (33.8% (27/80)), HPV58 (21.3% (17/80)) and HPV33 (13.75% (11/80)). About a third (37.5%, 30/80) of women with HPV had HR-HPV. Multiple HPV coinfections were common in HIV-HPV coinfected women (41.3%, 33/80). Cytological examinations revealed that 77.5% (62/80) HPV+ women had detectable cervical lesions. In comparison, only 4.9% (5/103) HPV negative womenwith Atypia and 1.0% (1/103) with CIN1 were diagnosed. Multivariate logistic regression revealed that HPV16 (OR=19.04, 2.53 to 122.92; p=0.004) and HPV18 (OR=11.54, 1.45 to 91.64; p=0.021) infections were significantly associated with CIN2+ in HIV-HPV coinfected women. Conclusion: A high prevalence of HPV was found in women on ART. HPV16/18 infection are strong associated factors to CIN2+ in HIV-HPV coinfected women.

KW - cervical neoplasia

KW - HIV

KW - HPV

KW - women

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U2 - 10.1136/sextrans-2018-053636

DO - 10.1136/sextrans-2018-053636

M3 - Article

VL - 95

SP - 140

EP - 144

JO - Sexually Transmitted Infections

JF - Sexually Transmitted Infections

SN - 1368-4973

IS - 2

ER -