Human nephron number: Implications for health and disease

John Bertram, Rebecca Douglas-Denton, Boucar Diouf, Michael Hughson, Wendy Hoy

Research output: Contribution to journalArticleResearchpeer-review

268 Citations (Scopus)

Abstract

Several studies have shown that total nephron (glomerular) number varies widely in normal human kidneys. Whereas the studies agree that average nephron number is approximately 900,000 to 1 million per kidney, numbers for individual kidneys range from approximately 200,000 to >2.5 million. Several studies have shown loss of glomeruli due to age-related glomerulosclerosis. The rates of loss vary among individuals depending upon blood pressure, diseases affecting the kidney, and other attributes of health, but most of the variation in nephron number is present at birth and is therefore developmentally determined. For example, in a relatively small study of nephron number in 15 children
Original languageEnglish
Pages (from-to)1529 - 1533
Number of pages5
JournalPediatric Nephrology
Volume26
Issue number9
DOIs
Publication statusPublished - 2011

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