TY - JOUR
T1 - Human mineralocorticoid receptor genomic structure and identification of expressed isoforms
AU - Zennaro, Maria-Christina
AU - Keightley, Maria-Cristina
AU - Kotelevtsev, Yumi
AU - Conway, Gerard S.
AU - Soubrier, Florent
AU - Fuller, Peter J.
PY - 1995
Y1 - 1995
N2 - Most of the known effects of aldosterone are mediated by the mineralocorticoid receptor, an intracellular receptor belonging to the steroid/thyroid hormone/retinoic acid receptor superfamily. We determined the genomic structure of the human MR (hMR) and identified 10 exons in the gene, including two exons (1α and 1β) that encode different 5'-untranslated sequence. Expression of the two different hMR variants is under the control of two different promoters that contain no obvious TATA element, but multiple GC boxes. Our results indicate that hMR expression is regulated by alternative promoters perhaps in a tissue- or developmental-specific manner.
AB - Most of the known effects of aldosterone are mediated by the mineralocorticoid receptor, an intracellular receptor belonging to the steroid/thyroid hormone/retinoic acid receptor superfamily. We determined the genomic structure of the human MR (hMR) and identified 10 exons in the gene, including two exons (1α and 1β) that encode different 5'-untranslated sequence. Expression of the two different hMR variants is under the control of two different promoters that contain no obvious TATA element, but multiple GC boxes. Our results indicate that hMR expression is regulated by alternative promoters perhaps in a tissue- or developmental-specific manner.
UR - http://www.scopus.com/inward/record.url?scp=0029155010&partnerID=8YFLogxK
U2 - 10.1074/jbc.270.36.21016
DO - 10.1074/jbc.270.36.21016
M3 - Article
C2 - 7673127
AN - SCOPUS:0029155010
SN - 0021-9258
VL - 270
SP - 21016
EP - 21020
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
IS - 36
ER -