Human kidney cell reprogramming: applications for disease modeling and personalized medicine

Adam C O'Neill, Sharon Denise Ricardo

Research output: Contribution to journalArticleResearchpeer-review

18 Citations (Scopus)

Abstract

The ability to reprogram fully differentiated cells into a pluripotent embryonic state, termed induced pluripotent stem cells (iPSCs), has been met with great excitement. iPSC technology has advanced the fundamental study of disease modeling with the potential for cell-replacement therapy, especially in the neuronal and cardiac fields. However, renal medicine as of yet has not benefited from similar advancements. This review summarizes the unique characteristics of iPSCs and their potential applications for modeling kidney disease. Pioneering such endeavors could yield constructs that recapitulate disease phenotypes, open avenues for more targeted drug development, and potentially serve as replenishable sources for replacement of kidney cells in the setting of human disease.
Original languageEnglish
Pages (from-to)1347 - 1356
Number of pages10
JournalJournal of the American Society of Nephrology
Volume24
Issue number9
DOIs
Publication statusPublished - 2013

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