Human intestinal gas measurement systems: In vitro fermentation and gas capsules

Jian Zhen Ou, C. K. Yao, Asaf Rotbart, Jane G. Muir, Peter R. Gibson, Kourosh Kalantar-Zadeh

Research output: Contribution to journalReview ArticleResearchpeer-review

98 Citations (Scopus)


The biological and clinical significance of the human gut microbiome is currently attracting worldwide attention. While rRNA and DNA technologies led to a quantum leap in our understanding of the numbers and types of gut microorganisms, much less is known about these microorganisms' activity in situ and in real time. Accurately measuring their byproducts, including intestinal gases, may offer unique biomarkers for specific gut microbiota, accelerating our understanding of the relationships among intestinal gases, the metabolic activity of the gut microbiome, and human health states. Here we present two novel techniques, namely in vitro fermentation and gas capsule systems, for measuring and assessing selected gas species. We discuss new developments with these technologies and the methods of their implementation and provide an overall review of their operation.

Original languageEnglish
Pages (from-to)208-213
Number of pages6
JournalTrends in Biotechnology
Issue number4
Publication statusPublished - 1 Apr 2015


  • Gas capsule
  • Gut microbiome
  • In vitro fermentation
  • Intestinal gas
  • Therapeutics

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