Human intestinal gas measurement systems: In vitro fermentation and gas capsules

Jian Zhen Ou; C. K. Yao; Asaf Rotbart; Jane G. Muir; Peter R. Gibson; Kourosh Kalantar-Zadeh

doi:10.1016/j.tibtech.2015.02.002

Human intestinal gas measurement systems: In vitro fermentation and gas capsules

Jian Zhen Ou, C. K. Yao, Asaf Rotbart, Jane G. Muir, Peter R. Gibson, Kourosh Kalantar-Zadeh

Gastroenterology

Research output: Contribution to journal › Review Article › Research › peer-review

113 Citations (Scopus)

Abstract

The biological and clinical significance of the human gut microbiome is currently attracting worldwide attention. While rRNA and DNA technologies led to a quantum leap in our understanding of the numbers and types of gut microorganisms, much less is known about these microorganisms' activity in situ and in real time. Accurately measuring their byproducts, including intestinal gases, may offer unique biomarkers for specific gut microbiota, accelerating our understanding of the relationships among intestinal gases, the metabolic activity of the gut microbiome, and human health states. Here we present two novel techniques, namely in vitro fermentation and gas capsule systems, for measuring and assessing selected gas species. We discuss new developments with these technologies and the methods of their implementation and provide an overall review of their operation.

Original language	English
Pages (from-to)	208-213
Number of pages	6
Journal	Trends in Biotechnology
Volume	33
Issue number	4
DOIs	https://doi.org/10.1016/j.tibtech.2015.02.002
Publication status	Published - 1 Apr 2015

Keywords

Gas capsule
Gut microbiome
In vitro fermentation
Intestinal gas
Therapeutics

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.tibtech.2015.02.002

Cite this

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title = "Human intestinal gas measurement systems: In vitro fermentation and gas capsules",

abstract = "The biological and clinical significance of the human gut microbiome is currently attracting worldwide attention. While rRNA and DNA technologies led to a quantum leap in our understanding of the numbers and types of gut microorganisms, much less is known about these microorganisms' activity in situ and in real time. Accurately measuring their byproducts, including intestinal gases, may offer unique biomarkers for specific gut microbiota, accelerating our understanding of the relationships among intestinal gases, the metabolic activity of the gut microbiome, and human health states. Here we present two novel techniques, namely in vitro fermentation and gas capsule systems, for measuring and assessing selected gas species. We discuss new developments with these technologies and the methods of their implementation and provide an overall review of their operation.",

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AU - Ou, Jian Zhen

AU - Yao, C. K.

AU - Rotbart, Asaf

AU - Muir, Jane G.

AU - Gibson, Peter R.

AU - Kalantar-Zadeh, Kourosh

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AB - The biological and clinical significance of the human gut microbiome is currently attracting worldwide attention. While rRNA and DNA technologies led to a quantum leap in our understanding of the numbers and types of gut microorganisms, much less is known about these microorganisms' activity in situ and in real time. Accurately measuring their byproducts, including intestinal gases, may offer unique biomarkers for specific gut microbiota, accelerating our understanding of the relationships among intestinal gases, the metabolic activity of the gut microbiome, and human health states. Here we present two novel techniques, namely in vitro fermentation and gas capsule systems, for measuring and assessing selected gas species. We discuss new developments with these technologies and the methods of their implementation and provide an overall review of their operation.

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KW - Gut microbiome

KW - In vitro fermentation

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Human intestinal gas measurement systems: In vitro fermentation and gas capsules

Abstract

Keywords

UN SDGs

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Human Gas Capsule

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Human intestinal gas measurement systems: In vitro fermentation and gas capsules

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Projects

Human Gas Capsule

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