TY - JOUR
T1 - Human induced pluripotent stem cells
T2 - The past, present, and future
AU - Hussein, S. M I
AU - Nagy, K.
AU - Nagy, A.
PY - 2011/5
Y1 - 2011/5
N2 - A major breakthrough in the past 5 years is the development of the ability to reprogram somatic cells to pluripotency. It has rejuvenated the field of stem cell research, providing regenerative medicine with new possibilities. In this paper, we discuss the progress made in the reprogramming field with focus on induction methodologies, the use of induced pluripotent stem cells (iPSCs) for drug discovery, and issues and precautions related to their use in regenerative medicine.
AB - A major breakthrough in the past 5 years is the development of the ability to reprogram somatic cells to pluripotency. It has rejuvenated the field of stem cell research, providing regenerative medicine with new possibilities. In this paper, we discuss the progress made in the reprogramming field with focus on induction methodologies, the use of induced pluripotent stem cells (iPSCs) for drug discovery, and issues and precautions related to their use in regenerative medicine.
UR - http://www.scopus.com/inward/record.url?scp=79955479900&partnerID=8YFLogxK
U2 - 10.1038/clpt.2011.37
DO - 10.1038/clpt.2011.37
M3 - Article
C2 - 21430659
AN - SCOPUS:79955479900
SN - 0009-9236
VL - 89
SP - 741
EP - 745
JO - Clinical Pharmacology & Therapeutics
JF - Clinical Pharmacology & Therapeutics
IS - 5
ER -