Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 983 - 990 |
| Number of pages | 8 |
| Journal | Menopause |
| Volume | 20 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - 2013 |
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Human immunodeficiency virus and menopause. / Kanapathipillai, Rupa; Hickey, Martha; Giles, Michelle Leanne.
In: Menopause, Vol. 20, No. 9, 2013, p. 983 - 990.Research output: Contribution to journal › Article › Other
TY - JOUR
T1 - Human immunodeficiency virus and menopause
AU - Kanapathipillai, Rupa
AU - Hickey, Martha
AU - Giles, Michelle Leanne
PY - 2013
Y1 - 2013
N2 - OBJECTIVE: This article aims to review currently available evidence for women infected with human immunodeficiency virus (HIV) and menopause and to propose clinical management algorithms. METHODS: Key studies addressing HIV and menopause have been reviewed, specifically age of menopause onset in HIV-infected women, frequency of menopausal symptoms, comorbidities associated with HIV and aging (including cardiovascular disease and bone disease), treatment of menopausal symptoms, and prevention of comorbidities in HIV-infected women. RESULTS: Studies suggest an earlier onset of menopause in HIV-infected women, with increased frequency of symptoms. Cardiovascular disease risk may be increased in this population, with combination antiretroviral therapy (cART) and chronic inflammation associated with HIV, contributing to increased risk. Chronic inflammation and cART have been independently implicated in bone disease. No published data have assessed the safety and efficacy of hormone therapy in relation to symptoms of menopause, cardiovascular risk, and bone disease among HIV-infected women. CONCLUSIONS: Few studies on menopause have been conducted in HIV-infected women compared with HIV-uninfected women. Many questions regarding age of menopause onset, frequency of menopausal symptoms and associated complications such as bone disease and cardiovascular disease, and efficacy of treatment among HIV-infected women remain. The incidence and severity of some of these factors may be increased in the setting of HIV and cART. ? 2013 by The North American Menopause Society.
AB - OBJECTIVE: This article aims to review currently available evidence for women infected with human immunodeficiency virus (HIV) and menopause and to propose clinical management algorithms. METHODS: Key studies addressing HIV and menopause have been reviewed, specifically age of menopause onset in HIV-infected women, frequency of menopausal symptoms, comorbidities associated with HIV and aging (including cardiovascular disease and bone disease), treatment of menopausal symptoms, and prevention of comorbidities in HIV-infected women. RESULTS: Studies suggest an earlier onset of menopause in HIV-infected women, with increased frequency of symptoms. Cardiovascular disease risk may be increased in this population, with combination antiretroviral therapy (cART) and chronic inflammation associated with HIV, contributing to increased risk. Chronic inflammation and cART have been independently implicated in bone disease. No published data have assessed the safety and efficacy of hormone therapy in relation to symptoms of menopause, cardiovascular risk, and bone disease among HIV-infected women. CONCLUSIONS: Few studies on menopause have been conducted in HIV-infected women compared with HIV-uninfected women. Many questions regarding age of menopause onset, frequency of menopausal symptoms and associated complications such as bone disease and cardiovascular disease, and efficacy of treatment among HIV-infected women remain. The incidence and severity of some of these factors may be increased in the setting of HIV and cART. ? 2013 by The North American Menopause Society.
U2 - 10.1097/GME.0b013e318282aa57
DO - 10.1097/GME.0b013e318282aa57
M3 - Article
VL - 20
SP - 983
EP - 990
JO - Menopause
JF - Menopause
SN - 1072-3714
IS - 9
ER -