Human hepatitis B virus infection of tree shrews and Macaca assamensis in vivo

Shu sheng Wang, Jian jia Su, Hua yuan Zhang, Yuan Li, Tao Zhang, You chun Wang, Guo yong Huang, Liu liang Qin, Xian min Ge, Yang Yu, He min Li

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4 Citations (Scopus)

Abstract

OBJECTIVE: To examine sensitivity of the tree shrews and Macaca assamensis to human hepatitis B virus (HHBV) by serologic methods. METHODS: Totally 233 tree shrews and 28 Macaca assamensis were inoculated with human sera containing HBV. After inoculation, the sera were collected weekly from them and HBV markers were detected with HBV ditecting ELISA kits. RESULTS: Ninety percent of the tree shrews developed acute infection, among them, 44.4 % persisted for over one year, 33.3% of them developed chronic infection persisted for 2 years and one month; the persistence of HBV in Macaca assamensis was much shorter. CONCLUSION: These data clearly indicated that tree shrew may be used as an animal model for study of chronic HBV infection, whereas, Macaca assamensis, showed only a transient sensitivity to HHBV.

Original languageEnglish
Pages (from-to)21-24
Number of pages4
JournalChinese Journal of Experimental and Clinical Virology
Volume17
Issue number1
Publication statusPublished - Mar 2003
Externally publishedYes

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