Human fetal growth restriction: A cardiovascular journey through to adolescence

A. Sehgal, Michael R Skilton, F. Crispi

Research output: Contribution to journalReview ArticleResearchpeer-review

21 Citations (Scopus)


Intrauterine growth restriction has been noted to adversely impact morbidity and mortality in the neonatal period as well as cardiovascular well-being in adolescence and adulthood. Recent data based on a wide range of ultrasound parameters during fetal and neonatal life has noted early and persistent involvement of the cardiovascular system. Some of these measures are predictive of long-term morbidities. Assessment of vascular mechanics is a new and novel concept in this population, and opens up avenues for diagnosis, monitoring and evaluation of the likely effectiveness of interventions. Prevention of these adverse vascular and cardiac outcomes secondary to fetal growth restriction may be feasible and of clinical relevance. This review focuses on growth restriction in humans with respect to cardiovascular remodeling and dysfunction during fetal life, persistence of functional cardiac impairment during early childhood and adoles cence, and possible preventive strategies.

Original languageEnglish
Pages (from-to)626-635
Number of pages10
JournalJournal of Developmental Origins of Health and Disease
Issue number6
Publication statusPublished - 1 Dec 2016


  • cardiovascular function
  • dietary interventions
  • fetal ultrasound
  • intrauterine growth restriction
  • omega-3 supplementation

Cite this