Human exfoliated deciduous teeth stem cells: Features and therapeutic effects on neurogenerative and hepatobiliary-pancreatic diseases

Nurul W.A. Wahab, Rhanye M. Guad, Vetriselvan Subramaniyan, Ismail M. Fareez, Ker W. Choy, Srinivasa R. Bonam, Chandrasekaran Selvaraju, Maw S. Sim, Subash C.B. Gopinath, Yuan S. Wu

Research output: Contribution to journalReview ArticleResearchpeer-review

4 Citations (Scopus)


Stem cells can multiply into more cells with similar types in an undifferentiated form and differentiate into other types of cells. The great success and key essence of stem cell technology is the isolation of high-quality Mesenchymal Stem Cells (MSCs) with high potency, either with multipotent or pluripotent property. In this line, Stem cells from Human Exfoliated Deciduous teeth (SHEDs) are highly proliferative stem cells from dental pulp and have multipoint differentiation capacity. These cells play a pivotal role in regenerative medicine, such as cell repair associated with neurodegenerative, hepatobiliary, and pancreatic diseases. In addition, stem cell therapy has been widely used to regulate immune response and repair of tissue lesions. This overview captured the differential biological characteristics, and the potential role of stem cell technology and paid special attention to human welfare SHEDs in eliminating the above-mentioned diseases. This review provides further insights into stem cell technology by expanding the therapeutic potential of SHEDs in tissue engineering and cell organ repairs.

Original languageEnglish
Pages (from-to)563-576
Number of pages14
JournalCurrent Stem Cell Research and Therapy
Issue number5
Publication statusPublished - 2021
Externally publishedYes


  • Diabetes mellitus
  • Human exfoliated deciduous teeth
  • Liver diseases
  • Neurodegenerative disease
  • Organ transplantation
  • Pluripotent
  • Retinal degeneration
  • SHEDs
  • Totipotency

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