Human cytomegalovirus (CMV)-specific CD8+ T cell responses are reduced in HIV-infected individuals with a history of CMV disease despite CD4+ T cell recovery

K P Singh, J L Howard, S P Wild, S L Jones, Jennifer F Hoy, Sharon R Lewin

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14 Citations (Scopus)

Abstract

Cytomegalovirus (CMV)-specific immunity was investigated in human immunodeficiency virus (HIV)-infected individuals. A case-control (1:2) study was performed with cases defined as having a history of CMV end-organ disease (n=15) and controls (n=30) matched by current CD4(+) T cell count. CMV-specific CD8(+) T cells responses were quantified using the high throughput Quantiferon-CMV test (Cellestis, Melbourne, Australia). 40/44 (91 ) had a positive Quantiferon-CMV test and the magnitude of response to CMV peptides correlated significantly with response to mitogen (p
Original languageEnglish
Pages (from-to)200 - 206
Number of pages7
JournalClinical Immunology
Volume124
Issue number2
Publication statusPublished - 2007

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