Human brain structural change related to acute single exposure to sarin

Hidenori Yamasue, Osamu Abe, Kyoto Kasai, Motomu Suga, Akira Iwanami, Haruyasu Yamada, Mamoru Tochigi, Toshiyuki Ohtani, Mark Andrew Rogers, Tsukasa Sasaki, Shigeki Aoki, Tadafumi Kato, Nobumasa Kato

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109 Citations (Scopus)


Objective: This study aimed to identify persistent morphological changes subsequent to an acute single-time exposure to satin, a highly poisonous organophosphate, and the neurobiological basis of long-lasting somatic and cognitive symptoms in victims exposed to satin. Methods: Thirty-eight victims of the 1995 Tokyo subway satin attack, all of whom had been treated in an emergency department for satin intoxication, and 76 matched healthy control subjects underwent T1-weighted and diffusion tensor magnetic resonance imaging (DTI) in 2000 to 2001. Serum cholinesterase (ChE) levels measured immediately and longitudinally after the exposure and the current severity of chronic reports in the victims were also evaluated. Results: The voxel-based morphometry exhibited smaller than normal regional brain volumes in the insular cortex and neighboring white matter, as well as in the hippocampus in the victims. The reduced regional white matter volume correlated with decreased serum cholinesterase levels and with the severity of chronic somatic complaints related to interoceptive awareness. Voxel-based analysis of diffusion tensor magnetic resonance imaging further demonstrated an extensively lower than normal fractional anisotropy in the victims. All these findings were statistically significant (corrected p <0.05). Interpretation: Sarin intoxication might be associated with structural changes in specific regions of the human brain, including those surrounding the insular cortex, which might be related to elevated subjective awareness of internal bodily status in exposed individuals.
Original languageEnglish
Pages (from-to)37 - 46
Number of pages10
JournalAnnals of Neurology
Issue number1
Publication statusPublished - 2007

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