Human amygdala volume is predicted by common DNA variation in the stathmin and serotonin transporter genes

D Stjepanovic, Valentina Lorenzetti, Murat Yucel, Ziarih Hawi, Mark Andrew Bellgrove

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Abstract

Despite the relevance of changes in amygdala volume to psychiatric illnesses and its heritability in both health and disease, the influence of common genetic variation on amygdala morphology remains largely unexplored. In the present study, we investigated the influence of a number of novel genetic variants on amygdala volume in 139 neurologically healthy individuals of European descent. Amygdala volume was significantly associated with allelic variation in the stathmin (STMN1) and serotonin transporter (SLC6A4) genes, which have been linked to healthy and disordered affective processing. These results were replicated across both manual and automated methods of amygdala parcellation, although manual tracing showed stronger effects, providing a cautionary note to studies relying on automated parcellation methods. Future studies will need to determine whether amygdala volume mediates the impact of stathmin and serotonin transporter gene variants on normal and dysfunctional emotion processing.
Original languageEnglish
Pages (from-to)1 - 7
Number of pages7
JournalTranslational Psychiatry
Volume3
Issue number3 (Art. No.: e283)
DOIs
Publication statusPublished - 2013

Cite this

@article{962940c5a2504394be7bcd2d264ec70a,
title = "Human amygdala volume is predicted by common DNA variation in the stathmin and serotonin transporter genes",
abstract = "Despite the relevance of changes in amygdala volume to psychiatric illnesses and its heritability in both health and disease, the influence of common genetic variation on amygdala morphology remains largely unexplored. In the present study, we investigated the influence of a number of novel genetic variants on amygdala volume in 139 neurologically healthy individuals of European descent. Amygdala volume was significantly associated with allelic variation in the stathmin (STMN1) and serotonin transporter (SLC6A4) genes, which have been linked to healthy and disordered affective processing. These results were replicated across both manual and automated methods of amygdala parcellation, although manual tracing showed stronger effects, providing a cautionary note to studies relying on automated parcellation methods. Future studies will need to determine whether amygdala volume mediates the impact of stathmin and serotonin transporter gene variants on normal and dysfunctional emotion processing.",
author = "D Stjepanovic and Valentina Lorenzetti and Murat Yucel and Ziarih Hawi and Bellgrove, {Mark Andrew}",
year = "2013",
doi = "10.1038/tp.2013.41",
language = "English",
volume = "3",
pages = "1 -- 7",
journal = "Translational Psychiatry",
issn = "2158-3188",
publisher = "Nature Publishing Group",
number = "3 (Art. No.: e283)",

}

Human amygdala volume is predicted by common DNA variation in the stathmin and serotonin transporter genes. / Stjepanovic, D; Lorenzetti, Valentina; Yucel, Murat; Hawi, Ziarih; Bellgrove, Mark Andrew.

In: Translational Psychiatry, Vol. 3, No. 3 (Art. No.: e283), 2013, p. 1 - 7.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Human amygdala volume is predicted by common DNA variation in the stathmin and serotonin transporter genes

AU - Stjepanovic, D

AU - Lorenzetti, Valentina

AU - Yucel, Murat

AU - Hawi, Ziarih

AU - Bellgrove, Mark Andrew

PY - 2013

Y1 - 2013

N2 - Despite the relevance of changes in amygdala volume to psychiatric illnesses and its heritability in both health and disease, the influence of common genetic variation on amygdala morphology remains largely unexplored. In the present study, we investigated the influence of a number of novel genetic variants on amygdala volume in 139 neurologically healthy individuals of European descent. Amygdala volume was significantly associated with allelic variation in the stathmin (STMN1) and serotonin transporter (SLC6A4) genes, which have been linked to healthy and disordered affective processing. These results were replicated across both manual and automated methods of amygdala parcellation, although manual tracing showed stronger effects, providing a cautionary note to studies relying on automated parcellation methods. Future studies will need to determine whether amygdala volume mediates the impact of stathmin and serotonin transporter gene variants on normal and dysfunctional emotion processing.

AB - Despite the relevance of changes in amygdala volume to psychiatric illnesses and its heritability in both health and disease, the influence of common genetic variation on amygdala morphology remains largely unexplored. In the present study, we investigated the influence of a number of novel genetic variants on amygdala volume in 139 neurologically healthy individuals of European descent. Amygdala volume was significantly associated with allelic variation in the stathmin (STMN1) and serotonin transporter (SLC6A4) genes, which have been linked to healthy and disordered affective processing. These results were replicated across both manual and automated methods of amygdala parcellation, although manual tracing showed stronger effects, providing a cautionary note to studies relying on automated parcellation methods. Future studies will need to determine whether amygdala volume mediates the impact of stathmin and serotonin transporter gene variants on normal and dysfunctional emotion processing.

UR - http://www.nature.com/tp/journal/v3/n7/pdf/tp201341a.pdf

U2 - 10.1038/tp.2013.41

DO - 10.1038/tp.2013.41

M3 - Article

VL - 3

SP - 1

EP - 7

JO - Translational Psychiatry

JF - Translational Psychiatry

SN - 2158-3188

IS - 3 (Art. No.: e283)

ER -