TY - JOUR
T1 - HPA axis functioning associated with transition to psychosis: Combined DEX/CRH test
AU - Thompson, K N
AU - Berger, G
AU - Phillips, Lisa J
AU - Komesaroff, Paul Alter
AU - Purcell, Rosemary
AU - McGorry, Patrick D
PY - 2007
Y1 - 2007
N2 - We investigated functioning of the hypothalamic-pituitary-adrenal (HPA) axis in 12 young people at ultra high risk for developing psychosis, using the combined dexamethasone corticotrophin releasing hormone (DEX/CRH) test. Over a two year period, three of the 12 participants developed an acute psychosis. Descriptive analysis of the data indicated that contrary to expectations, participants who did not make the transition to psychosis had on average higher cortisol levels at the latter stages of the test, as well as a greater severity of depression and anxiety symptoms, than participants who subsequently developed psychosis. These preliminary results suggest that dysregulated HPA-axis functioning in individuals at high risk for psychosis may be associated more with comorbid depression symptoms than factors specifically related to the process of emerging psychosis illness. (c) 2005 Elsevier Ltd. All rights reserved.
AB - We investigated functioning of the hypothalamic-pituitary-adrenal (HPA) axis in 12 young people at ultra high risk for developing psychosis, using the combined dexamethasone corticotrophin releasing hormone (DEX/CRH) test. Over a two year period, three of the 12 participants developed an acute psychosis. Descriptive analysis of the data indicated that contrary to expectations, participants who did not make the transition to psychosis had on average higher cortisol levels at the latter stages of the test, as well as a greater severity of depression and anxiety symptoms, than participants who subsequently developed psychosis. These preliminary results suggest that dysregulated HPA-axis functioning in individuals at high risk for psychosis may be associated more with comorbid depression symptoms than factors specifically related to the process of emerging psychosis illness. (c) 2005 Elsevier Ltd. All rights reserved.
UR - http://www.elsevier.com/locate/jpsychires
M3 - Article
SN - 0022-3956
VL - 41
SP - 446
EP - 450
JO - Journal of Psychiatric Research
JF - Journal of Psychiatric Research
IS - 5
ER -