How to ventilate patients without ARDS?

F. D. Simonis, A. Braber, H. P. Gelissen, J. Heidt, J. Horn, G. Innemee, E. de Jonge, N. P. Juffermans, P. E. Spronk, P. R. Tuinman, M. Vriends, R. B. de Wilde, A. Serpa Neto, M. Gama de Abreu, P. Pelosi, M. J. Schultz

Research output: Contribution to journalReview ArticleResearchpeer-review


Certain mechanical ventilation strategies could prevent the injury caused by this intervention. One element of so-called ‘lung–protective’ ventilation is the use of low tidal volumes. It is uncertain whether high levels of positive end-expiratory pressures have lung-protective properties as well. There are indications that high oxygen fractions of inspired air, or high blood oxygen targets, are harmful. This review summarises recently obtained clinical evidence for protective roles of low tidal volumes, high levels of PEEP, and low fractions of inspired oxygen in surgery patients, and critically ill patients without ARDS.

Original languageEnglish
Pages (from-to)14-18
Number of pages5
JournalNetherlands Journal of Critical Care
Issue number3
Publication statusPublished - Jun 2015
Externally publishedYes


  • Critical care
  • Intensive care unit
  • Intra–operative ventilation
  • Mechanical ventilation
  • Non injured lungs
  • Oxygen fraction
  • Positive end–expiratory pressure
  • Protective ventilation
  • Tidal volume
  • Ventilation–associated lung injury

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