How to perform first trimester combined screening for pre-eclampsia

Pre‐eclampsia is a common condition that affects 2–5% of pregnancies and is associated with significant maternal and perinatal morbidity, and cost to the healthcare system. In those at high risk for pre‐eclampsia, interventions such as aspirin intake have been shown to reduce prevalence of disease. However, to implement these interventions, it is essential that high‐risk women be identified early in pregnancy. A combined first trimester screening model for pre‐eclampsia that includes maternal history, mean arterial pressure, uterine artery Doppler and PlGF has been shown to be the most effective at identifying the population at greatest risk of pre‐eclampsia. This article will explore the most appropriate methods of measuring the components of first trimester screening and discuss the use of aspirin for prevention of pre‐eclampsia in pregnancy.