How to fabricate robust microfluidic systems for a dollar

Florian Lapierre, Neil R. Cameron, John Oakeshott, Thomas Peat, Yonggang Zhu

Research output: Chapter in Book/Report/Conference proceedingConference PaperResearchpeer-review

Abstract

Since the past decade, the interest towards microfluidic devices has sensibly grown due to the wide variety of multidisciplinary applications. One branch of the microfluidic domain consists in the synthesis of various types of emulsions requested by cosmetic, food and biotechnological industries In particular, monodisperse water-in-oil microemulsion synthetised in microfluidic devices are quickly becoming the new generation of emulsions for precise bead control and high surface area. These microemulsions are generally aqueous bioreactors in the form of droplets from 500 nm to 10 μm in diameter, enclosed in an oil environment. An increasing demand for bigger emulsions has led us to investigate new techniques for fabricating fluidic devices allowing a better control over the final size of the droplets. An easy, cheap, reproducible and fast technology for generating emulsions in the range of 100s μm with high throughout (up to mL/h) is reported. Simply using pipette tips and tubing, an innovative microfluidic device was fabricated, able to synthetise water-in-oil emulsions within the range 50 - 500 μm and double emulsions. These new emulsions are currently used for the synthesis of highly porous polymers beads from High Internal Phase Emulsion (HIPE). These beads will find high potential in 3D cell culture due to their high porosity (up to 90%) and pore size (from 5 to 30μm).

Original languageEnglish
Title of host publicationMicro/Nano Materials, Devices, and Systems
PublisherSPIE
Pages1-6
Number of pages6
Volume8923
ISBN (Print)9780819498144
DOIs
Publication statusPublished - 2013
Externally publishedYes
EventConference on Micro/Nano Materials, Devices, and Systems 2013 - RMIT University, Melbourne, Australia
Duration: 9 Dec 201311 Dec 2013

Conference

ConferenceConference on Micro/Nano Materials, Devices, and Systems 2013
Country/TerritoryAustralia
CityMelbourne
Period9/12/1311/12/13
OtherProceedings of SPIE Vol. 8923

Keywords

  • double emulsion
  • Emulsion
  • microbeads
  • microfluidics
  • polyHIPE

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