How is AMPK activity regulated in skeletal muscles during exercise?

Sebastian Beck Jorgensen, Adam J. Rose

Research output: Contribution to journalReview ArticleResearchpeer-review

38 Citations (Scopus)


AMPK is a metabolic "master" controller activated in skeletal muscle by exercise in a time and intensity dependent manner, and has been implicated in regulating metabolic pathways in muscle during physical exercise. AMPK signaling in skeletal muscle is regulated by several systemic and intracellular factors and the regulation of skeletal muscle AMPK in response to exercise is the focus of this review. Specifically, the role of LKB1 and phosphatase PP2C in nucleotide-dependent activation of AMPK, and ionized calcium in CaMKK-dependent activation of AMPK in working muscle is discussed. We also discuss the influence of reactive oxygen species produced within the muscle as well as muscle glycogen and TAK1 in regulating AMPK during exercise. Currently, during intensive contraction, activation of alpha2-AMPK seems mainly to rely on AMP accumulating from ATPhydrolysis whereas calcium signaling may have some importance during more gentle contraction conditions. Factors that regulate alpha1-AMPK during exercise are less clear but it appears, at least to some extent, to rely on an adenine nucleotide-dependent mechanism.

Original languageEnglish
Pages (from-to)5589-5604
Number of pages16
JournalFrontiers in Bioscience
Issue number14
Publication statusPublished - 1 May 2008
Externally publishedYes


  • AMP
  • AMP-activated protein kinase
  • Ca
  • Calcium signaling
  • Calmodulin-dependent protein kinases kinase
  • CaMKK
  • Cellular signaling
  • Exercise
  • Glycogen
  • LKB1
  • Metabolism
  • PP2C
  • Protein phosphatase 2C
  • Reactive oxygen species
  • Review
  • ROS
  • Skeletal muscle
  • TAK1

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