How effective are dietary interventions for prevention and management of chronic wounds in individuals with diabetes: a systematic review protocol

Background Adequate nutrition is essential for individuals with diabetes and wounds to optimise both wound healing and blood glucose control. Previous systematic reviews have evaluated the effectiveness of nutrition supplementation for wound healing in individuals with diabetes. However, none have reported comprehensively on the range of dietary interventions utilised in this population, despite these being common within clinical practice. Therefore, the aim of this systematic review is firstly to evaluate the effectiveness of dietary interventions for wound prevention and management in people with diabetes, and secondly to describe intervention characteristics. Methods Using PRISMA-P to guide the review, five databases will be searched for intervention studies (Medline, Embase, CINAHL, Scopus, Cochrane Library) as well as clinical trials registries. The Rob-2 and ROBINS tools will assess risk of bias. Studies will be described narratively, and a meta-analysis conducted if adequate levels of homogeneity exist between included studies and outcome variables, including study types, and characteristics of the sample including sample size. An appropriate model will be chosen to undertake meta-analysis. Discussion The systematic review results will inform clinicians on the most effective dietary interventions to optimise wound healing in individuals with diabetes. Study results will inform design and conduct of future nutrition interventions in wound healing.