How does low molecular weight heparin compare with unfractionated heparin for avoiding heparin-induced thrombocytopenia in people undergoing surgery?

Sera Tort, Carolina Weller, Cochrane Clinical Answers Editors

Research output: Contribution to journalArticleOtherpeer-review


Among people undergoing surgery (total hip arthroplasty; major surgical procedures such as endoprosthesis for fracture of humerus, hip/pelvis, femur, head of tibia, tibia, or knee; or minor surgical procedures), low molecular weight heparin may be more effective than unfractionated heparin in reducing the number of people with heparin-induced thrombocytopenia (HIT; on average, 5 vs 22 per 1000 people) and the number of people with HIT complicated by venous thromboembolism (4 vs 17 per 1000 people). However, these results should be treated with caution, as they are based on low-quality evidence. No trial reported the incidence of HIT complicated by arterial thrombosis, amputation, or death, or the incidence of venous leg ulceration.
Original languageEnglish
JournalCochrane Clinical Answers
Publication statusPublished - 8 Nov 2017

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