How a home-grown T cell receptor interacts with a foreign landscape

Jamie Rossjohn, James McCluskey

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)


The ability of a T cell receptor (TCR) to directly recognize foreign (allogeneic)-major histocompatibility complex (MHC) molecules underlies T cell-mediated rejection in patients receiving allogeneic organ transplants. In this issue, Colf et al. (2007) reveal that instead of mimicking the interactions formed with a self MHC, a single TCR adopts a completely different strategy to recognize a foreign MHC.
Original languageEnglish
Pages (from-to)19 - 20
Number of pages2
Issue number1
Publication statusPublished - 2007

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