Host parasite communications—Messages from helminths for the immune system: Parasite communication and cell-cell interactions

Gillian Coakley, Amy H. Buck, Rick M. Maizels

Research output: Contribution to journalArticleResearchpeer-review

45 Citations (Scopus)


Helminths are metazoan organisms many of which have evolved parasitic life styles dependent on sophisticated manipulation of the host environment. Most notably, they down-regulate host immune responses to ensure their own survival, by exporting a range of immuno-modulatory mediators that interact with host cells and tissues. While a number of secreted immunoregulatory parasite proteins have been defined, new work also points to the release of extracellular vesicles, or exosomes, that interact with and manipulate host gene expression. These recent results are discussed in the overall context of how helminths communicate effectively with the host organism.

Original languageEnglish
Pages (from-to)33-40
Number of pages8
JournalMolecular and Biochemical Parasitology
Issue number1
Publication statusPublished - 1 Jul 2016
Externally publishedYes


  • Parasite communications

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