Host defences to Citrobacter rodentium

Thomas T. MacDonald, Gad Frankel, Gordon Dougan, Nathalie S. Goncalves, Cameron Simmons

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33 Citations (Scopus)


Citrobacter rodentium is a natural non-invasive bacterial pathogen which infects the distal colon of mice. It uses the same molecular mechanisms of type III secretion as human enteropathogenic and enterohemorrhagic Escherichia coli to colonise the epithelial cells of the gut and is therefore an ideal model to study host-bacterial pathogen interactions in vivo. Infection elicits mucosal inflammation with similarities to inflammatory bowel disease, and so it is a readily accessible model to investigate the relationship between inflammation and anti-bacterial immunity in the gut.

Original languageEnglish
Pages (from-to)87-93
Number of pages7
JournalInternational Journal of Medical Microbiology
Issue number1
Publication statusPublished - 1 Jan 2003
Externally publishedYes


  • Citrobacter rodentium
  • Host immune responses
  • Intimin

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