Abstract
Citrobacter rodentium is a natural non-invasive bacterial pathogen which infects the distal colon of mice. It uses the same molecular mechanisms of type III secretion as human enteropathogenic and enterohemorrhagic Escherichia coli to colonise the epithelial cells of the gut and is therefore an ideal model to study host-bacterial pathogen interactions in vivo. Infection elicits mucosal inflammation with similarities to inflammatory bowel disease, and so it is a readily accessible model to investigate the relationship between inflammation and anti-bacterial immunity in the gut.
| Original language | English |
|---|---|
| Pages (from-to) | 87-93 |
| Number of pages | 7 |
| Journal | International Journal of Medical Microbiology |
| Volume | 293 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 1 Jan 2003 |
| Externally published | Yes |
Keywords
- Citrobacter rodentium
- Host immune responses
- Intimin
Cite this
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Host defences to Citrobacter rodentium. / MacDonald, Thomas T.; Frankel, Gad; Dougan, Gordon; Goncalves, Nathalie S.; Simmons, Cameron.
In: International Journal of Medical Microbiology, Vol. 293, No. 1, 01.01.2003, p. 87-93.Research output: Contribution to journal › Review Article › Research › peer-review
TY - JOUR
T1 - Host defences to Citrobacter rodentium
AU - MacDonald, Thomas T.
AU - Frankel, Gad
AU - Dougan, Gordon
AU - Goncalves, Nathalie S.
AU - Simmons, Cameron
PY - 2003/1/1
Y1 - 2003/1/1
N2 - Citrobacter rodentium is a natural non-invasive bacterial pathogen which infects the distal colon of mice. It uses the same molecular mechanisms of type III secretion as human enteropathogenic and enterohemorrhagic Escherichia coli to colonise the epithelial cells of the gut and is therefore an ideal model to study host-bacterial pathogen interactions in vivo. Infection elicits mucosal inflammation with similarities to inflammatory bowel disease, and so it is a readily accessible model to investigate the relationship between inflammation and anti-bacterial immunity in the gut.
AB - Citrobacter rodentium is a natural non-invasive bacterial pathogen which infects the distal colon of mice. It uses the same molecular mechanisms of type III secretion as human enteropathogenic and enterohemorrhagic Escherichia coli to colonise the epithelial cells of the gut and is therefore an ideal model to study host-bacterial pathogen interactions in vivo. Infection elicits mucosal inflammation with similarities to inflammatory bowel disease, and so it is a readily accessible model to investigate the relationship between inflammation and anti-bacterial immunity in the gut.
KW - Citrobacter rodentium
KW - Host immune responses
KW - Intimin
UR - http://www.scopus.com/inward/record.url?scp=0038636543&partnerID=8YFLogxK
U2 - 10.1078/1438-4221-00247
DO - 10.1078/1438-4221-00247
M3 - Review Article
VL - 293
SP - 87
EP - 93
JO - International Journal of Medical Microbiology
JF - International Journal of Medical Microbiology
SN - 1438-4221
IS - 1
ER -