Hospital outcomes of adult respiratory tract infections with extended-spectrum b-lactamase (ESBL) producing klebsiella pneuminiae

Li Cher Loh, Nor Izran Hanim bt Abdul Samad, Rosdara Masayuni bt Mohd Sani Sani, Sree Raman, Tarmizi Thayaparan, Shalini Kumar

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3 Citations (Scopus)

Abstract

Klebsiella pneumoniae ranks high as a cause of adult pneumonia requiring hospitalization in Malaysia. To study whether extended-spectrum b-lactamase (ESBL) producing K. pneumoniae was linked to hospital outcomes, we retrospectively studied 441 cases of adult respiratory tract infections with microbial proven K. pneumoniae from an urban-based university teaching hospital between 2003 and 2004. 47 (10.6%) cases had ESBL. Requirement for ventilation and median length of hospital stay, were greater in 'ESBL' than in 'non-ESBL' group [34% vs. 7.4%, p<0.001; 14 days vs. 5 days, p<0.001 respectively] but not crude hospital mortality rate [21.3% vs. 12.4%, p=0.092]. There was a four-fold increased risk of requiring ventilation [4.61 (2.72-7.85)] when ESBL was present. Our findings support the association of ESBL producing K. pneumoniae with adversed hospital outcomes and reiterate the need for vigilance on the part of treating clinicians.

Original languageEnglish
Pages (from-to)36-40
Number of pages5
JournalMalaysian Journal of Medical Sciences
Volume14
Issue number2
Publication statusPublished - Jul 2007
Externally publishedYes

Keywords

  • ESBL
  • Extended spectrum beta-lactamase
  • Hospitalization
  • Klebsiella pneumoniae
  • Malaysia
  • Mortality
  • Respiratory tract infections

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