TY - JOUR
T1 - Hormone replacement therapy
T2 - Current controversies
AU - Davison, Sonia
AU - Davis, Susan R.
PY - 2003/3/1
Y1 - 2003/3/1
N2 - Postmenopausal hormonal therapy is used to manage the climacteric symptoms that impair the quality of life of a substantial number of women. The difficulty is achieving the desired effects with minimal side-effects and no adverse health risks. Fundamental to this is understanding the physiology of oestrogen in women and the metabolism of the therapeutic compounds. Although the effects of oral oestrogen therapy have been studied extensively, there is insufficient evidence to assess adequately the independent effects of progestin use, other oestrogen compounds, differing doses and duration of treatment. We have reviewed some basic concepts of oestrogen physiology and how these relate to exogenous oestrogen administration, the risks of greatest concern, and the role of androgens and newer treatment alternatives.
AB - Postmenopausal hormonal therapy is used to manage the climacteric symptoms that impair the quality of life of a substantial number of women. The difficulty is achieving the desired effects with minimal side-effects and no adverse health risks. Fundamental to this is understanding the physiology of oestrogen in women and the metabolism of the therapeutic compounds. Although the effects of oral oestrogen therapy have been studied extensively, there is insufficient evidence to assess adequately the independent effects of progestin use, other oestrogen compounds, differing doses and duration of treatment. We have reviewed some basic concepts of oestrogen physiology and how these relate to exogenous oestrogen administration, the risks of greatest concern, and the role of androgens and newer treatment alternatives.
UR - http://www.scopus.com/inward/record.url?scp=0037336428&partnerID=8YFLogxK
U2 - 10.1046/j.1365-2265.2003.01774.x
DO - 10.1046/j.1365-2265.2003.01774.x
M3 - Review Article
C2 - 12608928
AN - SCOPUS:0037336428
SN - 0300-0664
VL - 58
SP - 249
EP - 261
JO - Clinical Endocrinology
JF - Clinical Endocrinology
IS - 3
ER -