Honeycomb-structured porous films from polypyrrole-containing block copolymers prepared via RAFT polymerization as a scaffold for cell growth

Danelle Beattie, Kok Hou Wong, Charles Williams, Laura A. Poole-Warren, Thomas P. Davis, Christopher Barner-Kowollik, Martina H. Stenzel

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187 Citations (Scopus)

Abstract

Honeycomb-structured porous films were prepared using customized amphiphilic block copolymers, synthesized by RAFT polymerization. Pyrrole was templated along an amphiphilic block copolymer, composed of polystyrene and poly(acrylic acid). Subsequent oxidation of pyrrol to polypyrrole, resulted in the formation of a soluble polypyrrole-containing polymer. Gel permeation chromatography and dynamic light scattering studies confirmed the solubility of the resulting customized amphiphilic block copolymer, in both water and organic solvent, forming either micelles or inverse aggregates. Porous films with a hexagonal array of micron-sized pores were generated with the polymer, using the breath figures templating technique. The resulting films were found to be non-cytotoxic and hence suitable as scaffolds for tissue engineering. Initial fibroblast cell culture studies on these scaffolds demonstrated a dependency of cell attachment on the pore size of scaffolds.

Original languageEnglish
Pages (from-to)1072-1082
Number of pages11
JournalBiomacromolecules
Volume7
Issue number4
DOIs
Publication statusPublished - 1 Apr 2006
Externally publishedYes

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