Homozygous mutation at cytochrome P4502D6 in an individual with schizophrenia: Implications for antipsychotic drugs, side effects and compliance

Michael Gill, Ziarih Hawi, Marcus Webb

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We report the case of a patient with schizophrenia who has suffered severe side effects with many different antipsychotics. She is poorly compliant with treatment probably because of her experiences with medication. We determined her genotype at the CYP2D6 gene that codes for an enzyme principally involved in the metabolism of many antipsychotics. She was homozygous for the 'B' mutation, the most frequent of several known mutations. She therefore has no functioning CYP2D6 enzyme in common with 5%-10% of the population. This may explain why she is sensitive to quite moderate doses of antipsychotic medication, and more rational prescribing may lead to fewer side effects and increased compliance.

Original languageEnglish
Pages (from-to)38-39
Number of pages2
JournalIrish Journal of Psychological Medicine
Issue number1
Publication statusPublished - 1997
Externally publishedYes


  • antipsychotic drugs
  • CYP2D6
  • cytochrome P450
  • genetics
  • side effects

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