Homology Modeling of GPCRs

John Watson Simms; Nathan Eric Hall; Polo HC Lam; Arthur Christopoulos; Ruben Abagyan; Patrick Sexton

Homology Modeling of GPCRs

John Watson Simms
, Nathan Eric Hall
, Polo HC Lam
, Arthur Christopoulos
, Ruben Abagyan
, Patrick Sexton

Pharmacology

Research output: Chapter in Book/Report/Conference proceeding › Chapter (Book) › Research › peer-review

12 Citations (Scopus)

Abstract

Over 1000 sequences likely to encode G protein-coupled receptors (GPCRs) are currently available in publicly accessible and proprietary databases and this number may grow with the refinement of a number of different genomes. However, despite recent efforts in the crystallization of these proteins, homology modeling approaches are becoming widely used as a method for obtaining quantitative and qualitative information for structure-based drug design as well as the interpretation of experimental data.

Original language	English
Title of host publication	Methods in Molecular Biology - G Protein-Coupled Receptors in Drug Delivery
Editors	Wayne R Leifert
Place of Publication	USA
Publisher	Humana Press
Pages	97 - 113
Number of pages	17
Edition	552
ISBN (Print)	9781603273169
Publication status	Published - 2009

Cite this

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abstract = "Over 1000 sequences likely to encode G protein-coupled receptors (GPCRs) are currently available in publicly accessible and proprietary databases and this number may grow with the refinement of a number of different genomes. However, despite recent efforts in the crystallization of these proteins, homology modeling approaches are becoming widely used as a method for obtaining quantitative and qualitative information for structure-based drug design as well as the interpretation of experimental data.",

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AU - Simms, John Watson

AU - Hall, Nathan Eric

AU - Lam, Polo HC

AU - Christopoulos, Arthur

AU - Abagyan, Ruben

AU - Sexton, Patrick

PY - 2009

Y1 - 2009

N2 - Over 1000 sequences likely to encode G protein-coupled receptors (GPCRs) are currently available in publicly accessible and proprietary databases and this number may grow with the refinement of a number of different genomes. However, despite recent efforts in the crystallization of these proteins, homology modeling approaches are becoming widely used as a method for obtaining quantitative and qualitative information for structure-based drug design as well as the interpretation of experimental data.

AB - Over 1000 sequences likely to encode G protein-coupled receptors (GPCRs) are currently available in publicly accessible and proprietary databases and this number may grow with the refinement of a number of different genomes. However, despite recent efforts in the crystallization of these proteins, homology modeling approaches are becoming widely used as a method for obtaining quantitative and qualitative information for structure-based drug design as well as the interpretation of experimental data.

UR - http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19513644

M3 - Chapter (Book)

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EP - 113

BT - Methods in Molecular Biology - G Protein-Coupled Receptors in Drug Delivery

A2 - Leifert, Wayne R

PB - Humana Press

CY - USA

ER -

Homology Modeling of GPCRs

Abstract

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