Homology Modeling of GPCRs

John Watson Simms, Nathan Eric Hall, Polo HC Lam, Arthur Christopoulos, Ruben Abagyan, Patrick Sexton

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

12 Citations (Scopus)


Over 1000 sequences likely to encode G protein-coupled receptors (GPCRs) are currently available in publicly accessible and proprietary databases and this number may grow with the refinement of a number of different genomes. However, despite recent efforts in the crystallization of these proteins, homology modeling approaches are becoming widely used as a method for obtaining quantitative and qualitative information for structure-based drug design as well as the interpretation of experimental data.
Original languageEnglish
Title of host publicationMethods in Molecular Biology - G Protein-Coupled Receptors in Drug Delivery
EditorsWayne R Leifert
Place of PublicationUSA
PublisherHumana Press
Pages97 - 113
Number of pages17
ISBN (Print)9781603273169
Publication statusPublished - 2009

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